2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenol

Base Information

Chemical Name:2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenol
CAS No.:1516886-02-4
Molecular Formula:C₂₃H₂₈N₂O₂S
Molecular Weight:396.554
Hs Code.:

Synonyms:2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenol

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Chemical Property of 2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenol

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Technology Process of 2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenol

There total 8 articles about 2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 910635-45-9
3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid

: 910635-33-5
3-ethyl-N,4-dihydroxy-5-methylbenzimidamide

: 1516886-02-4
2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenol

Guidance literature:: 3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

3-ethyl-N,4-dihydroxy-5-methylbenzimidamide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm401456d

Reference yield:

: 1073-13-8
4,4-dimethylcyclohexenone

: 1516886-02-4
2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenol

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 750.08 Torr

2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.5 h / 20 °C / Cooling with ice

2.2: 0.83 h / 15 - 20 °C

3.1: oxalyl dichloride / chloroform / 1 h / 20 - 25 °C

4.1: sodium; ethanol / tetrahydrofuran / 1 h / 20 °C

5.1: sodium; ethanol / 0.25 h / 50 - 75 °C

6.1: water; lithium hydroxide / ethanol / 70 °C

7.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

7.2: 3 h / -78 °C

8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

8.2: 18 h / 20 °C

With oxalyl dichloride; ethanol; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; tert.-butyl lithium; sodium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; pentane;
DOI:10.1021/jm401456d

Reference yield:

: C₁₃H₂₀O₃S

: 1516886-02-4
2-ethyl-4-(5-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium; ethanol / 0.25 h / 50 - 75 °C

2.1: water; lithium hydroxide / ethanol / 70 °C

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

3.2: 3 h / -78 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 18 h / 20 °C

With ethanol; water; tert.-butyl lithium; sodium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; pentane;
DOI:10.1021/jm401456d