4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one

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Chemical Name:4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one
CAS No.:1426699-31-1
Molecular Formula:C₁₇H₁₆BrClN₄O₂
Molecular Weight:423.697
Hs Code.:

Synonyms:4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one

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Chemical Property of 4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one

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Technology Process of 4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one

There total 4 articles about 4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426699-23-1
3-bromo-1-chloro-5-(1-chloroethyl)-4-methoxy-2-methylbenzene

: 306960-30-5
4-aminopyrido[2,3-d]pyrimidin-5(8H)-one

: 1426699-31-1
4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one

Guidance literature:: With caesium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 140 ℃; for 1h;

Reference yield:

: 1382996-38-4
1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethanol

: 1426699-31-1
4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

2: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 140 °C

With 1,3,5-trichloro-2,4,6-triazine; caesium carbonate; N,N-dimethyl-formamide; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 28478-40-2
1-(5-chloro-2-methoxy-4-methylphenyl)ethanone

: 1426699-31-1
4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetic acid / 18 h / 100 °C

2: sodium tetrahydroborate; methanol / 1 h / 20 °C

3: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

4: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 140 °C

With methanol; sodium tetrahydroborate; N-Bromosuccinimide; 1,3,5-trichloro-2,4,6-triazine; caesium carbonate; N,N-dimethyl-formamide; potassium iodide; In dichloromethane; acetic acid; N,N-dimethyl-formamide;