(3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

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Chemical Name:(3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one
CAS No.:699009-67-1
Molecular Formula:C₄₃H₅₄N₄O₄
Molecular Weight:690.926
Hs Code.:

(3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

Synonyms:(3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

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Chemical Property of (3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

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Technology Process of (3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

There total 1 articles about (3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 100-39-0
benzyl bromide

: 699009-62-6
1-[(3'R,6'S)-1'-benzyl-3',6'-dihydro-5'-ethoxy-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-3'',6''-dihydro-5''-ethoxy-6''-isopropylpyrazin-3''-yl-2''-one]-2-methylenepropane

: 699009-67-1
(3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.tetasy.2004.02.005

Reference yield: 100.0%

: 699009-67-1
(3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

: 699009-71-7
(3R,6S)-3-Benzyl-5-ethoxy-3-[2-((2R,5S)-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; at -50 ℃; for 0.0833333h;
DOI:10.1016/j.tetasy.2004.02.005

Reference yield:

: 699009-67-1
(3R,6S)-1,3-Dibenzyl-3-[2-((2R,5S)-4-benzyl-6-ethoxy-5-isopropyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-ylmethyl)-allyl]-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one

: (S)-2-[(2R,6R)-2,6-Diamino-2-benzyl-6-((S)-1-carboxy-2-methyl-propylcarbamoyl)-4-methylene-hexanoylamino]-3-methyl-butyric acid; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Li; liquid ammonia / tetrahydrofuran; 2-methyl-propan-2-ol / 0.08 h / -50 °C

2: 100 percent / HCl / H₂O / 48 h / 60 °C

With hydrogenchloride; ammonia; lithium; In tetrahydrofuran; water; tert-butyl alcohol; 1: Birch reaction;
DOI:10.1016/j.tetasy.2004.02.005