(R)-4-Isopropyl-3-{2-[(1R,2S)-2-(4-methoxy-benzyloxy)-4-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one

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Chemical Name:(R)-4-Isopropyl-3-{2-[(1R,2S)-2-(4-methoxy-benzyloxy)-4-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one
CAS No.:911236-73-2
Molecular Formula:C₃₃H₅₅NO₇Si
Molecular Weight:605.888
Hs Code.:

Synonyms:(R)-4-Isopropyl-3-{2-[(1R,2S)-2-(4-methoxy-benzyloxy)-4-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one

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Chemical Property of (R)-4-Isopropyl-3-{2-[(1R,2S)-2-(4-methoxy-benzyloxy)-4-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one

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Technology Process of (R)-4-Isopropyl-3-{2-[(1R,2S)-2-(4-methoxy-benzyloxy)-4-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one

There total 9 articles about (R)-4-Isopropyl-3-{2-[(1R,2S)-2-(4-methoxy-benzyloxy)-4-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₅₄O₇Si

: 95530-58-8
(R)-4-isopropyloxazolidin-2-one

: 911236-73-2
(R)-4-Isopropyl-3-{2-[(1R,2S)-2-(4-methoxy-benzyloxy)-4-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one

Guidance literature:: (R)-4-isopropyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

C₃₂H₅₄O₇Si; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.75h;
DOI:10.1021/ol0615782

Reference yield:

: 911236-94-7
(S)-4-(4-Methoxy-benzyloxy)-6-methyl-hept-6-ene-1,3-diol

: 911236-73-2
(R)-4-Isopropyl-3-{2-[(1R,2S)-2-(4-methoxy-benzyloxy)-4-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / imidazole / CH₂Cl₂

2.1: 100 percent / (COCl)2; DMSO / CH₂Cl₂ / 0.5 h / -78 °C

3.1: 79 percent / Zn(BH₄)2 / diethyl ether / -40 - -25 °C

4.1: NaH / dimethylformamide; tetrahydrofuran / 0.17 h / 0 °C

4.2: 90 percent / dimethylformamide; tetrahydrofuran / 0 - 20 °C

5.1: Et₃N / tetrahydrofuran / -78 - 0 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 27.6 g / tetrahydrofuran; hexane / 1.75 h / -78 - 0 °C

With 1H-imidazole; n-butyllithium; zinc(II) tetrahydroborate; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 2.1: Swern oxidation;
DOI:10.1021/ol0615782

Reference yield:

: 911236-70-9
(S)-4-(4-Methoxy-benzyloxy)-6-methyl-3-oxo-hept-6-enoic acid ethyl ester

: 911236-73-2
(R)-4-Isopropyl-3-{2-[(1R,2S)-2-(4-methoxy-benzyloxy)-4-methyl-1-(2-triisopropylsilanyloxy-ethyl)-pent-4-enyloxy]-acetyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 80 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

2.1: 100 percent / imidazole / CH₂Cl₂

3.1: 100 percent / (COCl)2; DMSO / CH₂Cl₂ / 0.5 h / -78 °C

4.1: 79 percent / Zn(BH₄)2 / diethyl ether / -40 - -25 °C

5.1: NaH / dimethylformamide; tetrahydrofuran / 0.17 h / 0 °C

5.2: 90 percent / dimethylformamide; tetrahydrofuran / 0 - 20 °C

6.1: Et₃N / tetrahydrofuran / -78 - 0 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

7.2: 27.6 g / tetrahydrofuran; hexane / 1.75 h / -78 - 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; zinc(II) tetrahydroborate; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1021/ol0615782