diethyl (1R,5R,6S,7S,R_S)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.0^1,5]undec-9-ene-3,3-dicarboxylate

Base Information

• Chemical Name: diethyl (1R,5R,6S,7S,R_S)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.0^1,5]undec-9-ene-3,3-dicarboxylate
• CAS No.: 439077-50-6
• Molecular Formula: C₂₉H₄₀O₈SSi
• Molecular Weight: 576.783

Synonyms:diethyl (1R,5R,6S,7S,R_S)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.0^1,5]undec-9-ene-3,3-dicarboxylate

Chemical Property of diethyl (1R,5R,6S,7S,R_S)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.0^1,5]undec-9-ene-3,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (1R,5R,6S,7S,R_S)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.0^1,5]undec-9-ene-3,3-dicarboxylate

There total 4 articles about diethyl (1R,5R,6S,7S,R_S)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.0^1,5]undec-9-ene-3,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-tert-butyldimethylsilyloxy-4-oxo-4H-pyran-2-yl)methyl chloride (152547-34-7) → diethyl (1R,5R,6S,7S,RS)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.01,5]undec-9-ene-3,3-dicarboxylate (439077-50-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

1.2: 75 percent / NaI / tetrahydrofuran / 4 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 70 percent / tetrahydrofuran / 12 h / 20 °C

3.1: toluene / 48 h / 160 °C

With sodium hydride; In tetrahydrofuran; toluene;

DOI:10.1002/1521-3765(20020215)8:4<884::AID-CHEM884>3.0.CO;2-Q

Reference yield:

diethyl malonate (105-53-3) → diethyl (1R,5R,6S,7S,RS)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.01,5]undec-9-ene-3,3-dicarboxylate (439077-50-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

1.2: 75 percent / NaI / tetrahydrofuran / 4 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

2.2: 70 percent / tetrahydrofuran / 12 h / 20 °C

3.1: toluene / 48 h / 160 °C

With sodium hydride; In tetrahydrofuran; toluene;

DOI:10.1002/1521-3765(20020215)8:4<884::AID-CHEM884>3.0.CO;2-Q

Reference yield:

diethyl 2-[(5-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]malonate (439079-38-6) → diethyl (1R,5R,6S,7S,RS)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.01,5]undec-9-ene-3,3-dicarboxylate (439077-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

1.2: 70 percent / tetrahydrofuran / 12 h / 20 °C

2.1: toluene / 48 h / 160 °C

With sodium hydride; In tetrahydrofuran; toluene;

DOI:10.1002/1521-3765(20020215)8:4<884::AID-CHEM884>3.0.CO;2-Q

upstream raw materials:

diethyl 2-[(5-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]-2-[(2E,R_S)-3-p-tolylsulfinyl-2-propenyl]malonate

(5-tert-butyldimethylsilyloxy-4-oxo-4H-pyran-2-yl)methyl chloride

diethyl malonate

diethyl 2-[(5-tert-butyldimethylsilyloxy-4-oxo-4H-2-pyranyl)methyl]malonate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 439077-50-6 diethyl (1R,5R,6S,7S,R_S)-9-tert-butyldimethylsilyloxy-8-oxo-6-(p-tolylsulfinyl)-11-oxatricyclo[5.3.1.0^1,5]undec-9-ene-3,3-dicarboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send