((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane

Base Information

Chemical Name:((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane
CAS No.:871589-71-8
Molecular Formula:C₂₆H₂₅F₇O₂
Molecular Weight:502.472
Hs Code.:

Synonyms:((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane

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Chemical Property of ((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane

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Technology Process of ((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane

There total 15 articles about ((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871589-70-7
N-methyl,N-methoxy ((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxamide

: 7103-09-5
4-but-1-enylmagnesium bromide

: 871589-71-8
((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane

Guidance literature:: N-methyl,N-methoxy ((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxamide; 4-but-1-enylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

: N-methyl,N-methoxy ((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)cyclopentanecarboxamide

: 7103-09-5
4-but-1-enylmagnesium bromide

: 871589-71-8
((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

Reference yield:

: 405512-86-9
((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentane-carboxylic acid

: 871589-71-8
((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.58 h / 0 - 20 °C

3: tetrahydrofuran / 2.5 h / 0 - 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;