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((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentane-carboxylic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

405512-86-9

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  • ((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentane-carboxylic acid

    Cas No: 405512-86-9

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405512-86-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 405512-86-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,5,1 and 2 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 405512-86:
(8*4)+(7*0)+(6*5)+(5*5)+(4*1)+(3*2)+(2*8)+(1*6)=119
119 % 10 = 9
So 405512-86-9 is a valid CAS Registry Number.

405512-86-9Relevant articles and documents

PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS

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Page/Page column 32-33; 44; 50, (2008/06/13)

The present invention is directed to a process for preparing certain α,α disubstituted γ-lactam derivatives that are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful i

COMBINATION THERAPY FOR THE TREATMENT OF URINARY FREQUENCY, URINARY URGENCY AND URINARY INCONTINENCE

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, (2010/11/29)

This invention concerns compositions for the treatment of urinary frequency, urinary urgency and urinary incontinence comprising a selected antagonist of the NK-1 receptor or a pharmaceutically acceptable salt thereof and an anti-muscarinic agent or a pha

Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Meurer, Laura C.,Finke, Paul E.,Owens, Karen A.,Tsou, Nancy N.,Ball, Richard G.,Mills, Sander G.,MacCoss, Malcolm,Sadowski, Sharon,Cascieri, Margaret A.,Tsao, Kwei-Lan,Chicchi, Gary G.,Egger, Linda A.,Luell, Silvi,Metzger, Joseph M.,MacIntyre, D. Euan,Rupniak, Nadia M.J.,Williams, Angela R.,Hargreaves, Richard J.

, p. 4504 - 4511 (2007/10/03)

The synthesis and optimization of a cyclopentane-based hNK1 antagonist scaffold 3, having four chiral centers, will be discussed in the context of its enhanced water solubility properties relative to the marketed anti-emetic hNK1 antagonist EMEND (Aprepitant). Sub-nanomolar hNK1 binding was achieved and oral activity comparable to Aprepitant in two in vivo models will be described.

Lactam tachykinin receptor antagonists

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Page/Page column 8; 9, (2010/02/15)

The present invention is directed to certain lactam compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations compri

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