(+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester

Base Information

• Chemical Name: (+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester
• CAS No.: 101268-42-2
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.284
• Mol file: 101268-42-2.mol

Synonyms:(+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester

Chemical Property of (+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester

There total 4 articles about (+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

2-Oxo-1-((E)-3-oxo-but-1-enyl)-cyclohexanecarboxylic acid ethyl ester → (+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester (101268-42-2) + 3-Keto-9-carbaethoxy-Δ1,4-hexahydro-naphthalin (98017-80-2) + 4-methylene-9-oxo-bicyclo[3.3.1]non-2-ene-1-carboxylic acid ethyl ester

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1016/S0040-4039(98)01500-7

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → (+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester (101268-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / K₂CO₃ / acetone / 40 h / 20 °C

2: 15 percent / pTsOH / toluene / Heating

With potassium carbonate; toluene-4-sulfonic acid; In acetone; toluene;

DOI:10.1016/S0040-4039(98)01500-7

Reference yield:

(E)-4-chloro-3-buten-2-one (4643-20-3) + 2-carboethoxycyclohexenone(1-)Na(1+) (75428-93-2) → (+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester (101268-42-2)

Guidance literature:

In benzene;

DOI:10.1016/0040-4020(61)80100-2

upstream raw materials:

(E)-4-chloro-3-buten-2-one

ethyl 2-oxocyclohexane carboxylate

2-carboethoxycyclohexenone^(1-)Na⁽¹⁺⁾

Downstream raw materials:

2-oxo-1-(3-oxo-butyl)-cyclohexanecarboxylic acid ethyl ester