75428-93-2

Upstream product

• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Downstream Products

• 33739-85-4 2-((Z)-4-Hydroxy-but-2-enyl)-cyclohexanone 
• 101101-17-1 (+/-)-2-oxo-1-(3-oxo-hex-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester 
• 101268-42-2 (+/-)-2-oxo-1-(3-oxo-but-1-en-t-yl)-cyclohexanecarboxylic acid ethyl ester 
• 14002-05-2 1-((Z)-4-Ethoxy-but-2-enyl)-2-oxo-cyclohexanecarboxylic acid ethyl ester 
• 101743-78-6 (+/-)-2-oxo-1-(3-oxo-3-phenyl-trans-propenyl)-cyclohexanecarboxylic acid ethyl ester 
• 115524-46-4 2-Oxo-1-[(E)-3-(toluene-4-sulfonyl)-allyl]-cyclohexanecarboxylic acid ethyl ester 
• 187737-37-7 propene 
• 75428-94-3 2-Aethoxycarbonyl-1-isopropyloxy-cyclohexen-1 
• 2890-55-3 1-isopropyl-2-oxo-cyclohexanecarboxylic acid ethyl ester 
• 75428-96-5 6-Aethoxycarbonyl-1-isopropyloxy-cyclohexen-1 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 115524-55-5 1-(Toluene-4-sulfonyl)-4,5,6,7-tetrahydro-indene-3a-carboxylic acid ethyl ester 
• 115524-54-4 7a-Hydroxy-1-(toluene-4-sulfonyl)-1,4,5,6,7,7a-hexahydro-indene-3a-carboxylic acid ethyl ester 
• 42797-81-9 2-(pent-4-ynyl)cyclohexanone 

Relevant academic research and scientific papers

The effect of crown ethers on the alkylation of a cyclic β-keto ester

The effects of crown ethers (6 and 7) on the reactions of sodium (2a) and potassium enolates (2b) of 2-ethoxycarbonylcyclohexanone (1) with isopropyl iodide in dimethylsulfoxide and dimethoxyethane have been investigated. When the addition of crown ether promoted dissociation of ion pair 2 in either of the two solvents, the total rate of reaction (kt) increased and the ratio of carbon- (3) to oxygen-alkylation (4 and 5) products decreased. The results are consistent with the involvement of both the ion pair and more dissociated species in alkylation and with greater reactivity for the latter.