(S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid

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Chemical Name:(S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid
CAS No.:1279027-79-0
Molecular Formula:C₂₆H₂₈FN₃O₅
Molecular Weight:481.524
Hs Code.:

Synonyms:(S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid

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Chemical Property of (S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid

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Technology Process of (S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid

There total 5 articles about (S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 736131-48-9,752198-38-2
(S)-3-amino-3-(2-methylphenyl)propionic acid

: 1318790-08-7
5-(3,3-dimethyl-2-oxobutoxy)-1-(2-fluorophenyl)-1H-pyrazole-3-carboxylic acid

: 1279027-79-0
(S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid

Guidance literature:: 5-(3,3-dimethyl-2-oxobutoxy)-1-(2-fluorophenyl)-1H-pyrazole-3-carboxylic acid; With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

(S)-3-amino-3-(2-methylphenyl)propionic acid; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 2924-15-4
(2-fluorophenyl)hydrazine hydrochloride

: 1279027-79-0
(S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / water / 2.42 h

2.1: thionyl chloride / 4 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 50 °C

4.1: water; lithium hydroxide / methanol / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 20 °C

With thionyl chloride; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; sulfuric acid; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 5-(3,3-dimethyl-2-oxobutoxy)-1-(2-fluorophenyl)-1H-pyrazole-3-carboxylic acid methyl ester

: 1279027-79-0
(S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / methanol / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

2.2: 20 °C

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; N,N-dimethyl-formamide;