6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine

Base Information

Chemical Name:6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine
CAS No.:154535-18-9
Molecular Formula:C₁₉H₂₀N₄O₂
Molecular Weight:336.393
Hs Code.:

Synonyms:6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine

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Chemical Property of 6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine

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Technology Process of 6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine

There total 5 articles about 6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1-t-butoxycarbonylphenyl-3-dicyanomethylene-4-(N,N-dimethylaminomethylene)pyrrolidine

: 154535-18-9
6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine

Guidance literature:: With methanol; ammonia; at 120 ℃; for 5h;
DOI:10.1002/jhet.5570300542

Reference yield:

: 18144-47-3
tert-butyl 4-aminobenzoate

: 154535-18-9
6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / potassium carbonate, triethyl phosphate / 10 h

2: 95 percent / DCC, pyridine, dimethyl sulfoxide, trifluoroacetic acid / benzene / 20 h / Ambient temperature

3: 60 percent / benzene / 1.5 h / 15 °C

4: 1.) lithium diisopropylamide mono(tetrahydrofuran), 2.) phosphorus oxychloride / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) cyclohexane, THF, -65 deg C, overnight

5: 98 percent / NH₃, methanol / 5 h / 120 °C

With pyridine; methanol; triethyl phosphate; ammonia; potassium carbonate; dimethyl sulfoxide; lithium diisopropylamide mono(tetrahydrofuran); dicyclohexyl-carbodiimide; trifluoroacetic acid; trichlorophosphate; In benzene;
DOI:10.1002/jhet.5570300542

Reference yield:

: 94930-28-6
N-<4'-(tert-butoxycarbonyl)phenyl>-3-pyrrolidinol

: 154535-18-9
6-amino-7-cyano-2-(t-butoxycarbonylphenyl)-2,3-dihydro-1H-pyrrolo<3,4-c>pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / DCC, pyridine, dimethyl sulfoxide, trifluoroacetic acid / benzene / 20 h / Ambient temperature

2: 60 percent / benzene / 1.5 h / 15 °C

3: 1.) lithium diisopropylamide mono(tetrahydrofuran), 2.) phosphorus oxychloride / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) cyclohexane, THF, -65 deg C, overnight

4: 98 percent / NH₃, methanol / 5 h / 120 °C

With pyridine; methanol; ammonia; dimethyl sulfoxide; lithium diisopropylamide mono(tetrahydrofuran); dicyclohexyl-carbodiimide; trifluoroacetic acid; trichlorophosphate; In benzene;
DOI:10.1002/jhet.5570300542