N-((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

Base Information

• Chemical Name: N-((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide
• CAS No.: 29724-89-8
• Molecular Formula: C₁₂H₁₆ClNO
• Molecular Weight: 225.718
• Mol file: 29724-89-8.mol

Synonyms:N-((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

Chemical Property of N-((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

There total 7 articles about N-((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dimethyl-3-phenylaziridine + acetyl chloride (75-36-5) → N-(1-Methyl-2-chlor-2-phenyl-ethyl)-N-methyl-acetamid (29724-89-8)

Guidance literature:

In benzene;

DOI:10.1246/bcsj.43.2591

Reference yield:

(±)-pseudoephedrine hydrochloride (50-98-6,134-71-4,345-78-8,670-40-6,24221-86-1,56979-55-6,63991-26-4,77262-74-9,77274-98-7) → N-((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide (29724-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

With thionyl chloride;

DOI:10.1002/ardp.19552881114

Reference yield:

acetyl chloride (75-36-5) → N-((1R,2R)-2-chloro-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide (29724-89-8)

Guidance literature:

With diethyl ether;

upstream raw materials:

acetyl chloride

(-)cis-(2S:3R)-N-Methyl-2-methyl-3-phenylaziridin

acetic anhydride

((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-methyl-amine

Downstream raw materials:

N-((1RS,2SR)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

ephedrine

acetic acid-((1S,2R)-2-methylamino-1-phenyl-propyl ester)