Technology Process of (2R,3S)-2-benzyl-3,4-(benzyloxycarbonylimino)-butanoic acid methyl ester
There total 7 articles about (2R,3S)-2-benzyl-3,4-(benzyloxycarbonylimino)-butanoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 0 ℃;
for 3h;
DOI:10.1021/jo0014055
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: LiHMDS / tetrahydrofuran; hexane / 2 h / -78 °C
1.2: 56 percent / tetrahydrofuran; hexane / 6 h
2.1: acetyl chloride / methanol / 3 h / 0 °C
2.2: CuCO3*Cu(OH)2 / H2O / 3 h / 70 °C
3.1: 5.8 g / Na2CO3 / H2O / 4 h / 20 °C
4.1: DCC / 1,2-dimethoxy-ethane
5.1: 7.3 g / NaBH4 / tetrahydrofuran / 18 h / 0 - 20 °C
6.1: 82 percent / DEAD; PPh3 / tetrahydrofuran / 3 h / 0 °C
With
sodium tetrahydroborate; sodium carbonate; acetyl chloride; dicyclohexyl-carbodiimide; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; water;
6.1: Intramolecular Mitsunobu reaction;
DOI:10.1021/jo0014055
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: LiHMDS / tetrahydrofuran; hexane / 2 h / -78 °C
1.2: 56 percent / tetrahydrofuran; hexane / 6 h
2.1: acetyl chloride / methanol / 3 h / 0 °C
2.2: CuCO3*Cu(OH)2 / H2O / 3 h / 70 °C
3.1: 5.8 g / Na2CO3 / H2O / 4 h / 20 °C
4.1: DCC / 1,2-dimethoxy-ethane
5.1: 7.3 g / NaBH4 / tetrahydrofuran / 18 h / 0 - 20 °C
6.1: 82 percent / DEAD; PPh3 / tetrahydrofuran / 3 h / 0 °C
With
sodium tetrahydroborate; sodium carbonate; acetyl chloride; dicyclohexyl-carbodiimide; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; water;
6.1: Intramolecular Mitsunobu reaction;
DOI:10.1021/jo0014055
