(4R,6R)-4-heptyl-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-2,2-dimethyl-1,3-dioxane

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Chemical Name:(4R,6R)-4-heptyl-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-2,2-dimethyl-1,3-dioxane
CAS No.:1262964-01-1
Molecular Formula:C₂₉H₄₆O₅
Molecular Weight:474.681
Hs Code.:

Synonyms:(4R,6R)-4-heptyl-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-2,2-dimethyl-1,3-dioxane

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Chemical Property of (4R,6R)-4-heptyl-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-2,2-dimethyl-1,3-dioxane

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Technology Process of (4R,6R)-4-heptyl-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-2,2-dimethyl-1,3-dioxane

There total 11 articles about (4R,6R)-4-heptyl-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-2,2-dimethyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1262964-00-0
(2R,4R)-1-((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)undecane-2,4-diol

: 77-76-9
2,2-dimethoxy-propane

: 1262964-01-1
(4R,6R)-4-heptyl-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-2,2-dimethyl-1,3-dioxane

Guidance literature:: With camphor-10-sulfonic acid; at 25 ℃; for 4h;
DOI:10.1021/ol1029854

Reference yield:

: 1262963-94-9
(4S,6S)-4-(iodomethyl)-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-1,3-dioxan-2-one

: 1262964-01-1
(4R,6R)-4-heptyl-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-2,2-dimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / 1 h / 25 °C

2.1: copper(l) iodide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

2.2: -20 - 20 °C / Inert atmosphere

3.1: camphor-10-sulfonic acid / 4 h / 25 °C

With copper(l) iodide; camphor-10-sulfonic acid; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1021/ol1029854

Reference yield:

: 1262963-95-0
(2S,6R)-6-allyl-2-[2-{(4-methoxybenzyl)oxy}ethyl]-3,6-dihydro-2H-pyran

: 1262964-01-1
(4R,6R)-4-heptyl-6-(((2R,6S)-6-(2-(4-methoxybenzyloxy)ethyl)-5,6-dihydro-2H-pyran-2-yl)methyl)-2,2-dimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water / 2 h / 20 °C

2.1: titanium(IV) isopropylate; (R)-1,1'-Bi-2-naphthol; titanium tetrachloride; silver(l) oxide / dichloromethane / -15 - 0 °C / Inert atmosphere; Darkness; Molecular sieve

3.1: dmap; triethylamine / dichloromethane / 5 h / 20 °C

4.1: N-iodo-succinimide / acetonitrile / -40 - 0 °C

5.1: potassium carbonate / methanol / 1 h / 25 °C

6.1: copper(l) iodide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

6.2: -20 - 20 °C / Inert atmosphere

7.1: camphor-10-sulfonic acid / 4 h / 25 °C

With 2,6-dimethylpyridine; titanium(IV) isopropylate; dmap; sodium periodate; N-iodo-succinimide; copper(l) iodide; osmium(VIII) oxide; camphor-10-sulfonic acid; (R)-1,1'-Bi-2-naphthol; titanium tetrachloride; potassium carbonate; triethylamine; silver(l) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; 4.1: Bartlett-Smith iodo-carbonate cyclization reaction;
DOI:10.1021/ol1029854