(4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one
CAS No.:858104-23-1
Molecular Formula:C₂₅H₂₉NO₅S
Molecular Weight:455.575
Hs Code.:

Synonyms:(4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one

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Chemical Property of (4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one

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Technology Process of (4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one

There total 2 articles about (4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 858104-22-0
({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetic acid

: 99395-88-7,7480-32-2
(S)-4-phenyl-2-oxazolidinone

: 858104-23-1
(4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one

Guidance literature:: ({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.5h;

(S)-4-phenyl-2-oxazolidinone; In dichloromethane; at 20 ℃; for 19h;

Reference yield:

: 858104-21-9
ethyl ({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetate

: 858104-23-1
(4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 0 - 20 °C

1.2: pH 3

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 0 °C

2.2: 19 h / 20 °C

With dmap; lithium hydroxide; water; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

Reference yield: 74.0%

: 858104-44-6
tert-butyl (4-{[(4-fluorophenyl)imino]methyl}phenoxy)acetate

: 858104-23-1
(4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one

: 858104-24-2
tert-butyl (4-{(1S,2R)-2-({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)-1-[(4-fluorophenyl)amino]-3-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]propyl}phenoxy)acetate

Guidance literature:: (4S)-3-[({[5,5-dimethyl-2-(4-methylphenyl)-1,3-dioxan-2-yl]methyl}thio)acetyl]-4-phenyl-1,3-oxazolidin-2-one; With titanium(IV) isopropylate; titanium tetrachloride; In dichloromethane; at 0 ℃; for 0.5h;

tert-butyl (4-{[(4-fluorophenyl)imino]methyl}phenoxy)acetate; In dichloromethane; at -30 - 0 ℃; for 0.833333h;

With water; N-ethyl-N,N-diisopropylamine; more than 3 stages;