tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate
CAS No.:1258428-87-3
Molecular Formula:C₃₆H₅₀FN₄O₉P
Molecular Weight:732.787
Hs Code.:

tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate

Synonyms:tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate

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Chemical Property of tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate

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Technology Process of tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate

There total 1 articles about tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258428-86-2
C₂HF₃O₂*C₂₂H₃₃FN₃O₆P

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1258428-87-3
tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;
DOI:10.1016/j.tet.2010.04.065

Reference yield: 70.0%

: 108-30-5
succinic acid anhydride

: 1258428-87-3
tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate

: 1258428-88-4
4-(((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: tert-butyl ((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenyl-propan-2-yl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

succinic acid anhydride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.tet.2010.04.065