2,5-diiodo-1,4-bis(hydroxymethyl)benzene diacetate

Base Information

• Chemical Name: 2,5-diiodo-1,4-bis(hydroxymethyl)benzene diacetate
• CAS No.: 915706-86-4
• Molecular Formula: C₁₂H₁₂I₂O₄
• Molecular Weight: 474.034
• Mol file: 915706-86-4.mol

Synonyms:2,5-diiodo-1,4-bis(hydroxymethyl)benzene diacetate

Chemical Property of 2,5-diiodo-1,4-bis(hydroxymethyl)benzene diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-diiodo-1,4-bis(hydroxymethyl)benzene diacetate

There total 2 articles about 2,5-diiodo-1,4-bis(hydroxymethyl)benzene diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1,4-bis(hydroxymethyl)benzene diacetate (14720-70-8) → 2,5-diiodo-1,4-bis(hydroxymethyl)benzene diacetate (915706-86-4)

Guidance literature:

With sulfuric acid; iodine; acetic acid; periodic acid; In tetrachloromethane; water; for 15h; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1021/acs.joc.8b02557

Reference yield:

p-xylylene glycol (589-29-7) → 2,5-diiodo-1,4-bis(hydroxymethyl)benzene diacetate (915706-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / pyridine / tetrahydrofuran / 20 °C

2: 23 percent / HIO₃; I₂; H₂SO₄ / acetic acid; CCl₄ / 15 h / Heating

With pyridine; sulfuric acid; iodine; iodic acid; In tetrahydrofuran; tetrachloromethane; acetic acid;

DOI:10.1055/s-2006-942534

Reference yield: 91.0%

2,5-diiodo-1,4-bis(hydroxymethyl)benzene diacetate (915706-86-4) → 2,5-diiodo-1,4-bis-(hydroxymethyl)benzene (915706-87-5)

Guidance literature:

With sodium hydroxide; In methanol; water; for 12h; Reflux;

DOI:10.1021/acs.joc.8b02557

upstream raw materials:

1,4-bis(hydroxymethyl)benzene diacetate

p-xylylene glycol

Downstream raw materials:

2,5-diiodo-1,4-bis-(hydroxymethyl)benzene

2,5-diiodo-1,4-bis(bromomethyl)benzene

Refernces

• 1、 Anan, Shizuka,Mochizuki, Yumi,Kokado, Kenta,Sada, Kazuki. "Step-Growth Copolymerization Between an Immobilized Monomer and a Mobile Monomer in Metal–Organic Frameworks". supporting information. p. 8018 - 8023. Retrieved 2019/05/16.