(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

Base Information

Chemical Name:(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol
CAS No.:1263497-44-4
Molecular Formula:C₂₆H₄₂O₃Si₂
Molecular Weight:458.789
Hs Code.:

Synonyms:(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

Suppliers and Price of (S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

Chemical Property:

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Technology Process of (S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

There total 7 articles about (S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1263497-43-3
(S)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

: 1263497-45-5
(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

: 1263497-44-4
(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

Guidance literature:: (S)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 1.5h;

With tert-butyl methyl ether; water; In hexane; dichloromethane; for 0.25h;
DOI:10.1055/s-0030-1258263

Reference yield:

: C₂₇H₄₂O₂Si₂

: 1263497-44-4
(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; tert-butyl alcohol; at 20 ℃; for 12h; Cooling with ice;
DOI:10.1021/acs.orglett.6b00713

Reference yield:

: 1360818-18-3
(S)-5-((tert-butyldimethylsilyl)oxy)pent-1-en-3-ol

: 1263497-44-4
(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 5 h / 20 °C / Cooling with ice

2: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tetrahydrofuran; tert-butyl alcohol / 12 h / 20 °C / Cooling with ice

With 1H-imidazole; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/acs.orglett.6b00713