(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

Base Information

Chemical Name:(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal
CAS No.:1263497-45-5
Molecular Formula:C₂₆H₄₀O₃Si₂
Molecular Weight:456.773
Hs Code.:

Synonyms:(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

Suppliers and Price of (S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

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Technology Process of (S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

There total 6 articles about (S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1263497-43-3
(S)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate

: 1263497-45-5
(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

: 1263497-44-4
(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

Guidance literature:: (S)-methyl 4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanoate; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 1.5h;

With tert-butyl methyl ether; water; In hexane; dichloromethane; for 0.25h;
DOI:10.1055/s-0030-1258263

Reference yield:

: 1263497-44-4
(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butan-1-ol

: 1263497-45-5
(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

Guidance literature:: With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; Molecular sieve;
DOI:10.1016/j.tetlet.2014.03.065

Reference yield:

: 1360818-18-3
(S)-5-((tert-butyldimethylsilyl)oxy)pent-1-en-3-ol

: 1263497-45-5
(S)-4-(tert-butyldimethylsilyloxy)-2-(tert-butyldiphenylsilyloxy)butanal

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 5 h / 20 °C / Cooling with ice

2: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tetrahydrofuran; tert-butyl alcohol / 12 h / 20 °C / Cooling with ice

3: sodium periodate; sodium hydrogencarbonate / tetrahydrofuran; water / 0.5 h / 0 - 20 °C

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/acs.orglett.6b00713