1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Base Information

Chemical Name:1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA
CAS No.:1307809-81-9
Molecular Formula:C₂HF₃O₂*C₂₇H₂₇F₃N₂O₃
Molecular Weight:598.542
Hs Code.:

Synonyms:1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

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Chemical Property of 1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

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Technology Process of 1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

There total 10 articles about 1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.5%

: 1307809-80-8
1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

: 76-05-1
trifluoroacetic acid

: 1307809-81-9
1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Guidance literature:: In methanol; water;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307809-81-9
1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: lithium diisopropyl amide / 0.2 h / 0 °C

4.2: 0.08 h / 110 °C

5.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 60 h / 20 °C

5.3: 0.5 h / 20 °C

6.1: methanol / acetic acid / 1,2-dichloro-ethane / 1 h / 80 °C

6.2: 0.5 h / 20 °C

7.1: water; methanol

With pyridine; methanol; osmium(VIII) oxide; hydroxylamine hydrochloride; sodium acetate; 4-methylmorpholine N-oxide; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane;

Reference yield:

: 1735-53-1
4-bromo-3-(trifluoromethyl)benzonitrile

: 1307809-81-9
1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 3 h / 20 - 70 °C / Inert atmosphere

1.2: 14 h / 110 °C

2.1: diazomethyl-trimethyl-silane / dichloromethane / 0.5 h / 0 °C

2.2: 20 °C

3.1: lithium diisopropyl amide / 0.2 h / 0 °C

3.2: 0.08 h / 110 °C

4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 60 h / 20 °C

4.3: 0.5 h / 20 °C

5.1: methanol / acetic acid / 1,2-dichloro-ethane / 1 h / 80 °C

5.2: 0.5 h / 20 °C

6.1: water; methanol

With methanol; osmium(VIII) oxide; 4-methylmorpholine N-oxide; lithium diisopropyl amide; diazomethyl-trimethyl-silane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane;