1735-53-1Relevant academic research and scientific papers
Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent
Shi, Guangfa,Shao, Changdong,Pan, Shulei,Yu, Jingxun,Zhang, Yanghui
supporting information, p. 38 - 41 (2015/07/28)
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions. (Chemical Equation Presented).
Fused bicyclic Gly-Asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere
Fisher, Matthew J.,Giese, Ulrich,Harms, Cathy S.,Kinnick, Michael D.,Lindstrom, Terry D.,McCowan, Jefferson R.,Mest, Hans-Juergen,Morin Jr., John M.,Mullaney, Jeffrey T.,Paal, Michael,Rapp, Achim,Ruehter, Gerd,Ruterbories, Ken J.,Sall, Daniel J.,Scarborough, Robert M.,Schotten, Theo,Stenzel, Wolfgang,Towner, Richard D.,Um, Suzane L.,Utterback, Barbara G.,Wyss, Virginia L.,Jakubowski, Joseph A.
, p. 385 - 389 (2007/10/03)
6-[4-Amidinobenzoyl]amino]-tetralone-2-acetic acid is a potent antagonist of GPIIb-IIIa. Substitution in the meta position of the benzamidine, or replacement with a heteroaryl amidine was tolerated in this series. Use of an acyl-linked 4-alkyl piperidine
Synthesis of 3-trifluoromethyl-4-halobenzonitriles
Yonezawa, Noriyuki,Hino, Tetsuo,Namie, Tsutomu,Katakai, Ryoichi
, p. 1575 - 1578 (2007/10/03)
The practical synthetic method for a series of substantially novel fluorine-containing polyfunctional aromatic compounds, 3-trifluoromethyl-4-halobenzonitriles [halo = Cl, Br, and F], was established by using copper-cyano complexes as effective Sandmeyer cyanating reagents.
