7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene

Base Information

Chemical Name:7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene
CAS No.:556068-01-0
Molecular Formula:C₂₃H₁₃NO₂
Molecular Weight:335.362
Hs Code.:

Synonyms:7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene

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Chemical Property of 7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene

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Technology Process of 7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene

There total 3 articles about 7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1785-07-5
2,7-dibromo-4-nitro-9H-fluorene

: 536-74-3
phenylacetylene

: 556067-70-0
(4'-bromo-3,2'-dinitro-biphenyl-4-ylethynyl)-trimethyl-silane

: 556068-01-0
7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene

Guidance literature:: 2,7-dibromo-4-nitro-9H-fluorene; phenylacetylene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 336h;

(4'-bromo-3,2'-dinitro-biphenyl-4-ylethynyl)-trimethyl-silane; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 55 - 60 ℃; for 30h;

With potassium carbonate; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(03)00334-X

Reference yield:

: 86-73-7
9H-fluorene

: 556068-01-0
7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / Br₂; ferric chloride / CHCl₃ / 3 h / 0 - 20 °C

2.1: 63 percent / HNO₃; H₂SO₄; AcOH / 0.67 h / 35 - 70 °C

3.1: copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 336 h / 20 °C

3.2: copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 30 h / 55 - 60 °C

3.3: potassium carbonate / methanol; CH₂Cl₂

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; bromine; nitric acid; iron(III) chloride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1016/S0040-4020(03)00334-X

Reference yield:

: 92-86-4
4-(4-bromophenyl)bromobenzene

: 556068-01-0
7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 70 percent / nitric acid / 0.67 h / 0 °C

2.1: 58 percent / copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 4 h / 20 °C

3.1: copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 336 h / 20 °C

3.2: copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 30 h / 55 - 60 °C

3.3: potassium carbonate / methanol; CH₂Cl₂

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; nitric acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2.1: Sonogashira coupling / 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1016/S0040-4020(03)00334-X