N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide

Base Information

Chemical Name:N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide
CAS No.:556068-03-2
Molecular Formula:C₃₀H₁₈N₂O₃
Molecular Weight:454.485
Hs Code.:

Synonyms:N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide

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Chemical Property of N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide

Chemical Property:

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Technology Process of N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide

There total 7 articles about N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6393-17-5
N-(4-iodo-phenyl)-formamide

: 556068-01-0
7-ethynyl-4-nitro-2-phenylethynyl-9H-fluorene

: 556068-03-2
N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 55 ℃; for 3h;
DOI:10.1016/S0040-4020(03)00334-X

Reference yield:

: 86-73-7
9H-fluorene

: 556068-03-2
N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / Br₂; ferric chloride / CHCl₃ / 3 h / 0 - 20 °C

2.1: 63 percent / HNO₃; H₂SO₄; AcOH / 0.67 h / 35 - 70 °C

3.1: copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 336 h / 20 °C

3.2: copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 30 h / 55 - 60 °C

3.3: potassium carbonate / methanol; CH₂Cl₂

4.1: copper(I) iodide; N,N-diisopropylethylamine; triphenylphosphine / bis(dibenzylideneacetone)palladium⁽⁰⁾ / tetrahydrofuran / 3 h / 55 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; bromine; nitric acid; iron(III) chloride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; chloroform; 3.1: Sonogashira coupling / 3.2: Sonogashira coupling / 4.1: Sonogashira coupling;
DOI:10.1016/S0040-4020(03)00334-X

Reference yield:

: 92-86-4
4-(4-bromophenyl)bromobenzene

: 556068-03-2
N-[4-(5-nitro-7-phenylethynyl-9H-fluoren-2-ylethynyl)-phenyl]-formamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 70 percent / nitric acid / 0.67 h / 0 °C

2.1: 58 percent / copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 4 h / 20 °C

3.1: copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 336 h / 20 °C

3.2: copper(I) iodide; N,N-diisopropylethylamine; bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 30 h / 55 - 60 °C

3.3: potassium carbonate / methanol; CH₂Cl₂

4.1: copper(I) iodide; N,N-diisopropylethylamine; triphenylphosphine / bis(dibenzylideneacetone)palladium⁽⁰⁾ / tetrahydrofuran / 3 h / 55 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; nitric acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 2.1: Sonogashira coupling / 3.1: Sonogashira coupling / 3.2: Sonogashira coupling / 4.1: Sonogashira coupling;
DOI:10.1016/S0040-4020(03)00334-X