carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-chroman-7-yl ester tert-butyl ester

Base Information

• Chemical Name: carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-chroman-7-yl ester tert-butyl ester
• CAS No.: 895918-07-7
• Molecular Formula: C₂₉H₃₈O₈
• Molecular Weight: 514.616
• Mol file: 895918-07-7.mol

Synonyms:carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-chroman-7-yl ester tert-butyl ester

Chemical Property of carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-chroman-7-yl ester tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-chroman-7-yl ester tert-butyl ester

There total 3 articles about carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-chroman-7-yl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

tri-tert-butyl (2-formylbenzene-1,3,5-triyl)tricarbonate (895918-06-6) + 4-tert-butoxystyrene (95418-58-9) → carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-chroman-7-yl ester tert-butyl ester (895918-07-7)

Guidance literature:

tri-tert-butyl (2-formylbenzene-1,3,5-triyl)tricarbonate; 4-tert-butoxystyrene; With magnesium dibromide etherate; In diethyl ether;

With lithium aluminium tetrahydride; In diethyl ether; at -78 - 20 ℃; for 3h;

DOI:10.1016/j.tet.2006.01.109

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-chroman-7-yl ester tert-butyl ester (895918-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 75 percent / Et(i-Pr)2N; 4-(dimethylamino)pyridine / CH₂Cl₂

2.1: magnesium bromide dietherate / diethyl ether

2.2: 45 percent / lithium aluminum hydride / diethyl ether / 3 h / -78 - 20 °C

With dmap; magnesium dibromide etherate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2006.01.109

Reference yield:

2,4,6-trihydroxybenzaldehyde (487-70-7) → carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-chroman-7-yl ester tert-butyl ester (895918-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 75 percent / Et(i-Pr)2N; 4-(dimethylamino)pyridine / CH₂Cl₂

2.1: magnesium bromide dietherate / diethyl ether

2.2: 45 percent / lithium aluminum hydride / diethyl ether / 3 h / -78 - 20 °C

With dmap; magnesium dibromide etherate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2006.01.109

upstream raw materials:

tri-tert-butyl (2-formylbenzene-1,3,5-triyl)tricarbonate

4-tert-butoxystyrene

di-tert-butyl dicarbonate

2,4,6-trihydroxybenzaldehyde

Downstream raw materials:

carbonic acid 5-tert-butoxycarbonyloxy-2-(4-tert-butoxy-phenyl)-4-oxo-chroman-7-yl ester tert-butyl ester

5,4'-dihydroxy-7-methoxyflavanone

eriodictyol

5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on