Welcome to LookChem.com Sign In|Join Free

CAS

  • or

487-70-7

Post Buying Request

487-70-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

487-70-7 Usage

Chemical Properties

pale pink crystalline powder

Uses

Different sources of media describe the Uses of 487-70-7 differently. You can refer to the following data:
1. Reactant involved in the synthesis of biologically active molecules including:? ;2,4,6-trichlorophenyl hydrazones with potential inhibition of protein glycation1? ;Esculentoside A derivatives with haemolytic activity and LPS-induced nitric oxide production inhibition2? ;α-Nucleophiles for hydrolysis of organophosphorus nerve agents3? ;Xanthine oxidase inhibitors4? ;Non-complexes Schiff base hydrazones5? ;Methylated (±)-epigallocatechin gallate library for anticancer activity studies6
2. 2,4,6-Trihydroxybenzaldehyde is a reactant involved in the synthesis of 2,4,6-trichlorophenyl hydrazones with potential inhibition of protein glycation and Xanthine oxidase inhibitors.

Check Digit Verification of cas no

The CAS Registry Mumber 487-70-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 7 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 487-70:
(5*4)+(4*8)+(3*7)+(2*7)+(1*0)=87
87 % 10 = 7
So 487-70-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H6O4/c8-3-5-6(10)1-4(9)2-7(5)11/h1-3,9-11H

487-70-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A19678)  2,4,6-Trihydroxybenzaldehyde, 95%   

  • 487-70-7

  • 1g

  • 292.0CNY

  • Detail
  • Alfa Aesar

  • (A19678)  2,4,6-Trihydroxybenzaldehyde, 95%   

  • 487-70-7

  • 5g

  • 868.0CNY

  • Detail
  • Alfa Aesar

  • (A19678)  2,4,6-Trihydroxybenzaldehyde, 95%   

  • 487-70-7

  • 25g

  • 3459.0CNY

  • Detail

487-70-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4,6-Trihydroxybenzaldehyde

1.2 Other means of identification

Product number -
Other names 2,4,6-TRIHYDROXYBENZALDEHYDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:487-70-7 SDS

487-70-7Synthetic route

1,3,5-Trihydroxybenzene dihydrate
6099-90-7

1,3,5-Trihydroxybenzene dihydrate

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With trichlorophosphate In ethyl acetate at 20℃; for 1h; Vilsmeier-Haack Formylation; Cooling with ice;98%
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
Stage #1: 3,5-dihydroxyphenol; N,N-dimethyl-formamide With oxalyl dichloride In acetonitrile at 0℃; for 0.5h;
Stage #2: With water at 80℃; for 2h;
96%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 0 - 25℃; for 0.5h; Vilsmeier-Haack Formylation;
Stage #2: 3,5-dihydroxyphenol In 1,4-dioxane at 0 - 25℃; for 3h; Vilsmeier-Haack Formylation; Inert atmosphere;
95%
With trichlorophosphate In ethyl acetate at 0 - 20℃; for 2h; Vilsmeier-Haack Formylation; Inert atmosphere;92%
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With trichlorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 4h; Inert atmosphere;80%
With hydrogenchloride; diethyl ether; mercury(II) fulminate Hydroysierung des Oxims;
2-(chloro-dimethylamino-methyl)-benzene-1,3,5-triol

2-(chloro-dimethylamino-methyl)-benzene-1,3,5-triol

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With water In methanol at 20℃; for 4h; Hydrolysis;79.2%
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

bromocyane
506-68-3

bromocyane

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With hydrogenchloride
With hydrogenchloride; diethyl ether; zinc(II) chloride Beim Kochen des Reaktionsprodukts mit Wasser;
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

hydrogen cyanide
74-90-8

hydrogen cyanide

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With hydrogenchloride
With hydrogenchloride; diethyl ether Erwaermen des ausfallenden salzsauren Aldimids mit Wasser und Schwefelsaeure;
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

Formanilid
103-70-8

Formanilid

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With diethyl ether; trichlorophosphate und Zerlegen des Reaktionsproduktes mit Wasser;
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

dichloromethyl-methyl sulfide
2032-76-0

dichloromethyl-methyl sulfide

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
(i) ZnCl2, Et2O, (ii) aq. HCl; Multistep reaction;
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

chloroform
67-66-3

chloroform

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With sodium hydroxide In water for 1h; Heating;
galangin
548-83-4

galangin

A

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

B

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
With 18-crown-6 ether In tetrahydrofuran; toluene Product distribution; -10 deg C, then room temp.;
kaempferol
520-18-3

kaempferol

A

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

B

4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

Conditions
ConditionsYield
With 18-crown-6 ether In tetrahydrofuran; toluene Product distribution; -10 deg C, then room temp.;
quercetol
117-39-5

quercetol

A

3,4-Dihydroxybenzoic acid
99-50-3

3,4-Dihydroxybenzoic acid

B

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With 18-crown-6 ether In tetrahydrofuran; toluene Product distribution; -10 deg C, then room temp.;
C47H81NO6SSi3

C47H81NO6SSi3

A

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

B

C22H33NO2S

C22H33NO2S

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran; hexane
hydrogenchloride
7647-01-0

hydrogenchloride

3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

diethyl ether
60-29-7

diethyl ether

zinc cyanide

zinc cyanide

A

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

B

2,4-diformyl 2,4,6-trihydroxybenzene
4396-13-8

2,4-diformyl 2,4,6-trihydroxybenzene

Conditions
ConditionsYield
Erwaermen des Reaktionsprodukts mit Wasser auf dem Dampfbad;
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

zinc cyanide

zinc cyanide

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With hydrogenchloride; diethyl ether
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

zinc cyanide

zinc cyanide

A

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

B

2,4-diformyl 2,4,6-trihydroxybenzene
4396-13-8

2,4-diformyl 2,4,6-trihydroxybenzene

Conditions
ConditionsYield
With hydrogenchloride; diethyl ether Erwaermen des Reaktionsprodukts mit Wasser;
sulfuric acid
7664-93-9

sulfuric acid

2,4,6-trihydroxy-benzaldehyde imine; sulfate

2,4,6-trihydroxy-benzaldehyde imine; sulfate

A

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

B

ammonium sulfate

ammonium sulfate

3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

ω-oxymethylen-acetoveratrone

ω-oxymethylen-acetoveratrone

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: POCl3 / 0.33 h / 0 °C
1.2: acetonitrile / 18 h / 20 °C
2.1: 79.2 percent / H2O / methanol / 4 h / 20 °C
View Scheme

A

3,4,5-trihydroxybenzoic acid
149-91-7

3,4,5-trihydroxybenzoic acid

B

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With water at 37℃; pH=7.4; Kinetics; aq. phosphate buffer;
cyanidin-3-glucoside chloride
7084-24-4, 27661-36-5

cyanidin-3-glucoside chloride

A

3,4-Dihydroxybenzoic acid
99-50-3

3,4-Dihydroxybenzoic acid

B

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With water at 37℃; pH=7.4; Kinetics; aq. phosphate buffer;
cyanidin chloride
528-58-5

cyanidin chloride

A

3,4-Dihydroxybenzoic acid
99-50-3

3,4-Dihydroxybenzoic acid

B

acide 2,4,6-trihydroxybenzoique
83-30-7

acide 2,4,6-trihydroxybenzoique

C

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 20℃; pH=4.8; Kinetics; pH-value;
malvidin 3-O-glucoside
18470-06-9

malvidin 3-O-glucoside

A

8-β-D-glucopyranosyl-2,4-dihydroxy-6-oxo-cyclohexa-2,4-dienylacetic acid

8-β-D-glucopyranosyl-2,4-dihydroxy-6-oxo-cyclohexa-2,4-dienylacetic acid

B

β-D-glucopyranosyl (2,4-dihydroxy-6-oxo-cyclohexa-2,4-dienylidene)acetate

β-D-glucopyranosyl (2,4-dihydroxy-6-oxo-cyclohexa-2,4-dienylidene)acetate

C

3,5-dimethoxy-4-hydroxybenzoic acid
530-57-4

3,5-dimethoxy-4-hydroxybenzoic acid

D

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

E

C23H26O14

C23H26O14

F

C17H16O9

C17H16O9

G

2,4,6-trihydroxyphenylacetylglucoside

2,4,6-trihydroxyphenylacetylglucoside

H

2,4,6-trihydroxy-phenylacetic acid

2,4,6-trihydroxy-phenylacetic acid

I

(Z)-1-(4-Hydroxy-3,5-dimethoxy-phenyl)-2-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3-(2,4,6-trihydroxy-phenyl)-propenone
109717-92-2

(Z)-1-(4-Hydroxy-3,5-dimethoxy-phenyl)-2-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3-(2,4,6-trihydroxy-phenyl)-propenone

Conditions
ConditionsYield
With water In acetonitrile at 35℃; for 72h; pH=1;
2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-on
491-70-3

2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-on

A

3,4-Dihydroxybenzoic acid
99-50-3

3,4-Dihydroxybenzoic acid

B

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

C

C15H10O7

C15H10O7

D

2-(3',4'-dihydroxybenzoyloxy)-4,6-dihydroxybenzoic acid
30048-34-1

2-(3',4'-dihydroxybenzoyloxy)-4,6-dihydroxybenzoic acid

E

2,5,7-trihydroxy-4H-1-benzopyran-4-one

2,5,7-trihydroxy-4H-1-benzopyran-4-one

F

3,5-dihydroxy-2-(2-oxoacetyl)phenyl-3,4-dihydroxybenzoate

3,5-dihydroxy-2-(2-oxoacetyl)phenyl-3,4-dihydroxybenzoate

G

3',4',5,6,7-pentahydroxyflavone
18003-33-3

3',4',5,6,7-pentahydroxyflavone

H

3,4-Dihydroxy-benzoic acid 2-formyl-3,5-dihydroxy-phenyl ester

3,4-Dihydroxy-benzoic acid 2-formyl-3,5-dihydroxy-phenyl ester

Conditions
ConditionsYield
With oxygen; potassium hydroxide In methanol
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

acetic anhydride
108-24-7

acetic anhydride

5,7-diacetoxyl-2-chromenone
21524-17-4

5,7-diacetoxyl-2-chromenone

Conditions
ConditionsYield
With sodium acetate at 190℃; for 14h;100%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

2,4,6-trihydroxytoluene
88-03-9

2,4,6-trihydroxytoluene

Conditions
ConditionsYield
With hydrogenchloride; zinc In diethyl ether; ethyl acetate for 0.166667h; Clemmensen Reduction; Cooling with ice;99%
With hydrogenchloride; zinc In diethyl ether; water; ethyl acetate for 0.166667h; Clemmensen Reduction; Cooling with ice;99%
With hydrogenchloride; methyl orange; sodium cyanoborohydride In tetrahydrofuran; water at 20℃; for 12h; pH=4;78%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

5-amino-1-(4-methoxyphenyl)-1H-imidazole-4-carbonitrile
155579-43-4

5-amino-1-(4-methoxyphenyl)-1H-imidazole-4-carbonitrile

C18H14N4O4
1610624-88-8

C18H14N4O4

Conditions
ConditionsYield
With trifluoroacetic acid In ethanol at 20℃;98%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

1,3,6,8‑tetrahydroxyxanthylium chloride

1,3,6,8‑tetrahydroxyxanthylium chloride

Conditions
ConditionsYield
With chloro-trimethyl-silane; acetic acid In methanol for 1h;98%
Stage #1: 2,4,6-trihydroxybenzaldehyde With hydrogenchloride; pentane-1,3-diol In 1,4-dioxane; water at 20℃; for 16h;
Stage #2: In 1,4-dioxane; n-heptane at 0℃; for 2h; Mechanism;
41%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

ethyl (2E)-3-(2,4,6-trihydroxyphenyl)arylate
1185256-07-8

ethyl (2E)-3-(2,4,6-trihydroxyphenyl)arylate

Conditions
ConditionsYield
In tetrahydrofuran at 30℃; for 8h;97%
(3,4-Dimethoxyphenyl)acetic acid
93-40-3

(3,4-Dimethoxyphenyl)acetic acid

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

5,7-dihydroxy-3-(3,4-dimethoxyphenyl)-coumarin

5,7-dihydroxy-3-(3,4-dimethoxyphenyl)-coumarin

Conditions
ConditionsYield
Stage #1: (3,4-Dimethoxyphenyl)acetic acid; 2,4,6-trihydroxybenzaldehyde With acetic anhydride; triethylamine at 112℃; for 1.16667h; Microwave irradiation; Green chemistry;
Stage #2: With hydrogenchloride In ethanol; water at 80℃; for 3h; Green chemistry;
96%
2-(2,5-dimethylthiazol-4-yl)acetohydrazide

2-(2,5-dimethylthiazol-4-yl)acetohydrazide

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

(E)-2-(2,5-dimethyl-1,3-thiazol-4-yl)-N-(2,4,6-trihydroxybenzylidene)acetohydrazide

(E)-2-(2,5-dimethyl-1,3-thiazol-4-yl)-N-(2,4,6-trihydroxybenzylidene)acetohydrazide

Conditions
ConditionsYield
With acetic acid In ethanol96%
5-nitrospiro[1,3-dioxolane-2,3’-indol]-2’(1’H)-one
113207-59-3

5-nitrospiro[1,3-dioxolane-2,3’-indol]-2’(1’H)-one

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

(E)-5′-((2,4,6-trihydroxybenzylidene)amino)spiro[[1,3]dioxolane-2,3′-indolin]-2′-one

(E)-5′-((2,4,6-trihydroxybenzylidene)amino)spiro[[1,3]dioxolane-2,3′-indolin]-2′-one

Conditions
ConditionsYield
With triethylamine In ethanol for 8h; Reflux;95%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

4-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzohydrazide

4-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzohydrazide

N’-(2,4,6-trihydroxybenzylidene)-4-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2yl)benzohydrazide

N’-(2,4,6-trihydroxybenzylidene)-4-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2yl)benzohydrazide

Conditions
ConditionsYield
With acetic acid In methanol for 3h; Reflux;94.1%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

m-Hydroxyaniline
591-27-5

m-Hydroxyaniline

2-{[(3-hydroxyphenyl)imino]methyl}benzene-1,3,5-triol

2-{[(3-hydroxyphenyl)imino]methyl}benzene-1,3,5-triol

Conditions
ConditionsYield
In water at 25℃; for 2h;94%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

2-bromo-1-(3,4-dichlorophenyl)ethanone
2632-10-2

2-bromo-1-(3,4-dichlorophenyl)ethanone

(3,4-dichlorophenyl)(4,6-dihydroxybenzofuran-2-yl)methanone

(3,4-dichlorophenyl)(4,6-dihydroxybenzofuran-2-yl)methanone

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃;94%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

thiosemicarbazide
79-19-6

thiosemicarbazide

2-(2,4,6-trihydroxybenzylidine)hydrazinecarbothioamide

2-(2,4,6-trihydroxybenzylidine)hydrazinecarbothioamide

Conditions
ConditionsYield
In ethanol; water Reflux;93.6%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2,4,6-tri-tert-butyldimethylsilyloxybenzaldehyde
265975-35-7

2,4,6-tri-tert-butyldimethylsilyloxybenzaldehyde

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; silylation;93%
2-hydrazinoquinoxaline
61645-34-9

2-hydrazinoquinoxaline

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

(E)-5-((2-(quinoxalin-2-yl)hydrazono)methyl)benzene-2,4,6-triol

(E)-5-((2-(quinoxalin-2-yl)hydrazono)methyl)benzene-2,4,6-triol

Conditions
ConditionsYield
With acetic acid In methanol for 3h; Reflux;93%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

4-methoxybenzoic acid hydrazide
3290-99-1

4-methoxybenzoic acid hydrazide

N'-(2,4,6-trihydroxybenzylidene)-4-methoxybenzohydrazide

N'-(2,4,6-trihydroxybenzylidene)-4-methoxybenzohydrazide

Conditions
ConditionsYield
With acetic acid In methanol for 3h; Reflux;92%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

α-bromoacetophenone
70-11-1

α-bromoacetophenone

(4,6-dihydroxybenzofuran-2-yl)(phenyl)methanone

(4,6-dihydroxybenzofuran-2-yl)(phenyl)methanone

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃;92%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

4-(bromoacetyl)toluene
619-41-0

4-(bromoacetyl)toluene

(4,6-dihydroxybenzofuran-2-yl)(p-tolyl)methanone

(4,6-dihydroxybenzofuran-2-yl)(p-tolyl)methanone

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃;92%
benzophenone hydrazone
5350-57-2

benzophenone hydrazone

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

2,4,6-trihydroxybenzaldehyde N-(diphenylmethylene)hydrazone

2,4,6-trihydroxybenzaldehyde N-(diphenylmethylene)hydrazone

Conditions
ConditionsYield
With acetic acid In ethanol Reflux;90%
With acetic acid In ethanol Reflux;
With acetic acid In methanol Reflux;
4-(3,4-dihydroxyphenyl)-3-buten-2-one

4-(3,4-dihydroxyphenyl)-3-buten-2-one

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

2-(3,4-dihydroxystyryl)-5,7-dihydroxy-1-benzopyrylium chloride

2-(3,4-dihydroxystyryl)-5,7-dihydroxy-1-benzopyrylium chloride

Conditions
ConditionsYield
With chloro-trimethyl-silane; ethyl acetate In methanol at 0 - 20℃; Aldol Condensation;90%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

3'-nitro-2-bromoacetophenone
2227-64-7

3'-nitro-2-bromoacetophenone

(4,6-dihydroxybenzofuran-2-yl)(3-nitrophenyl)methanone

(4,6-dihydroxybenzofuran-2-yl)(3-nitrophenyl)methanone

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃;90%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

4-(bis(1-methyl-1H-indol-3-yl)methyl)benzohydrazide

4-(bis(1-methyl-1H-indol-3-yl)methyl)benzohydrazide

(E)-4-(bis(1-methyl-1H-indol-3-yl)methyl)-N'-(2,4,6-trihydroxybenzylidene)benzohydrazide

(E)-4-(bis(1-methyl-1H-indol-3-yl)methyl)-N'-(2,4,6-trihydroxybenzylidene)benzohydrazide

Conditions
ConditionsYield
With acetic acid In methanol for 3h; Reflux;89.4%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

3-bromo-2,4,6-trihydroxybenzaldehyde

3-bromo-2,4,6-trihydroxybenzaldehyde

Conditions
ConditionsYield
With pyridinium hydrobromide perbromide In tetrahydrofuran at -20℃; for 3h;89%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

2-(3,5-dihydroxyphenyl)acetic acid
4670-09-1

2-(3,5-dihydroxyphenyl)acetic acid

acetic anhydride
108-24-7

acetic anhydride

5,7-diacetoxy-3-(3',5'-diacetoxyphenyl)coumarin
1255947-98-8

5,7-diacetoxy-3-(3',5'-diacetoxyphenyl)coumarin

Conditions
ConditionsYield
With triethylamine at 110℃;88%
With triethylamine at 120℃; for 8h; Perkin reaction; regioselective reaction;88%
1-bromo dodecane
112-29-8

1-bromo dodecane

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

2,4,6-tris(decyloxy)benzaldehyde
1000607-97-5

2,4,6-tris(decyloxy)benzaldehyde

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 110℃; for 48h;88%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 110℃; for 48h;88%
bromethyl methyl ether
13057-17-5

bromethyl methyl ether

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

2-hydroxy-4,6-bis(methoxymethoxy)benzaldehyde
1132988-93-2

2-hydroxy-4,6-bis(methoxymethoxy)benzaldehyde

Conditions
ConditionsYield
Stage #1: 2,4,6-trihydroxybenzaldehyde With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; Inert atmosphere;
Stage #2: bromethyl methyl ether In dichloromethane at 20℃; for 12h; Inert atmosphere;
88%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 3.5h; Inert atmosphere;76%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 3.5h; Inert atmosphere;76%
3-acetyl-4-hydroxybenzoic acid
16357-40-7

3-acetyl-4-hydroxybenzoic acid

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

C16H12O7

C16H12O7

Conditions
ConditionsYield
With sodium hydroxide In water Inert atmosphere; Reflux;88%
2-(2-bromo-4-hydroxyphenyl)acetic acid
88491-44-5

2-(2-bromo-4-hydroxyphenyl)acetic acid

2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

3-(2-bromo-4-hydroxyphenyl)-5,7-dihydroxycoumarin

3-(2-bromo-4-hydroxyphenyl)-5,7-dihydroxycoumarin

Conditions
ConditionsYield
With triethylamine In acetic anhydride at 110℃; for 7h; Temperature; Reagent/catalyst;88%
2,4,6-trihydroxybenzaldehyde
487-70-7

2,4,6-trihydroxybenzaldehyde

2-Bromo-4'-phenylacetophenone
135-73-9

2-Bromo-4'-phenylacetophenone

[1,1'-biphenyl]-4-yl(4,6-dihydroxybenzofuran-2-yl)methanone

[1,1'-biphenyl]-4-yl(4,6-dihydroxybenzofuran-2-yl)methanone

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃;88%

487-70-7Relevant articles and documents

Alternative routes to the acylphloroglucinol rhodomyrtone

Morkunas, Marius,Maier, Martin E.

, p. 9662 - 9666 (2015)

Two novel routes to the acylphloroglucinol rhodomyrtone (1) which has antibiotic properties are presented. In the first route an ortho-quinone methide, generated from dioxaborinine 23, is reacted with syncarpic acid (10) leading to xanthenedione 25. Cleavage of the methyl ether functions led to the known rhodomyrtone precursor 16. In the second route the bis-ester derivative 28 of trihydroxybenzaldehyde 26 is condensed with syncarpic acid (10) to give tricyclic hemiacetal 29. Acetalization and cuprate addition to the enone function led to bis-ester 32 which gave rhodomyrtone (1) by TiCl4-induced regioselective Fries rearrangement.

Anti-oxidant activity of flavonols: Reactivity with potassium superoxide in the heterogeneous phase

Tournaire,Hocquaux,Beck,Oliveros,Maurette

, p. 9303 - 9314 (1994)

Oxidation of flavonols by potassium superoxide (KO2) in heterogeneous aprotic media yields acids and aldehydes by opening of ring C, if the latter contains an ethylenic double bond substituted by an OH group. A mechanism is proposed for this reaction. Other flavonoids like flavones, flavans and flavanones induce only the disproportionation of superoxide anion, without undergoing further oxidation; these flavonoids are therefore anti-oxidants of particular interest.

Synthetic method of pilosin B and intermediate pseudomonophenols thereof

-

Paragraph 0040; 0066, (2021/11/26)

The invention discloses a method for synthesizing pilosin B and intermediate pseudomonophenols thereof. The synthesis method of the pseudo-sheep equol comprises the step E. Step F and Step g. The synthetic method of the pilosin B provided by the invention is prepared by the following steps H, step J, preparation of the pseudomonophenols synthesized by the above method, and preparation of the pseudomonophenols synthesized by the method in step I. In step E, the novel amino protecting reagent with good reaction with the phenolic hydroxyl group is used as a protecting reagent, the phenol hydroxyl group of each intermediate in the intermediate molecule fragment a synthesis process is selectively protected, the reagent types are reduced and the use of toxic reagents such as benzyl chloride and the like is avoided.

Synthesis and biological evaluation of BMS-986120 and its deuterated derivatives as PAR4 antagonists

Chen, Panpan,Ren, Shenhong,Song, Hangyu,Chen, Cai,Chen, Fangjun,Xu, Qinglong,Kong, Yi,Sun, Hongbin

, p. 116 - 124 (2018/11/30)

BMS-986120 is a PAR4 antagonist that is being investigated as an antiplatelet agent in phase I clinical trial. An improved synthesis of BMS-986120 has been developed. Based on the novel synthetic approach to BMS-986120, a series of deuterated derivatives of BMS-986120 have been synthesized and biologically evaluated to search for more potent antiplatelet agents. The in vitro antiplatelet assay by turbidimetry demonstrated that PC-2 and PC-6 had IC50 values of 6.30 nM and 6.97 nM, respectively, versus BMS-986120 with an IC50 of 7.80 nM. The result of in vitro metabolic stability study showed that all of the deuterated compounds had similar half-life (T1/2) and intrinsic clearance (Clint) in comparison with BMS-986120. Further probing the metabolic profile of BMS-986120 is worth being conducted.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 487-70-7