17-benzyl 16-tert-butyl 5-methyl (5S,16S,17R)-19-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-4,10-diazaicosane-5,16,17-tricarboxylate

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Chemical Name:17-benzyl 16-tert-butyl 5-methyl (5S,16S,17R)-19-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-4,10-diazaicosane-5,16,17-tricarboxylate
CAS No.:359821-16-2
Molecular Formula:C₃₈H₅₄N₂O₁₀
Molecular Weight:698.854
Hs Code.:

Synonyms:17-benzyl 16-tert-butyl 5-methyl (5S,16S,17R)-19-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-4,10-diazaicosane-5,16,17-tricarboxylate

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Chemical Property of 17-benzyl 16-tert-butyl 5-methyl (5S,16S,17R)-19-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-4,10-diazaicosane-5,16,17-tricarboxylate

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Technology Process of 17-benzyl 16-tert-butyl 5-methyl (5S,16S,17R)-19-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-4,10-diazaicosane-5,16,17-tricarboxylate

There total 5 articles about 17-benzyl 16-tert-butyl 5-methyl (5S,16S,17R)-19-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-4,10-diazaicosane-5,16,17-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 5591-93-5
(S)-methyl 6-amino-2-(benzyloxycarbonylamino)hexanoate

: 191407-51-9
1-benzyl 4-tert-butyl (2R,3S)-2-isobutyl-3-(3-{[(4-nitrophenoxy)carbonyl]oxy}propyl)butanedioate

: 359821-16-2
17-benzyl 16-tert-butyl 5-methyl (5S,16S,17R)-19-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-4,10-diazaicosane-5,16,17-tricarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;
DOI:10.1021/jm010127e

Reference yield:

: 100-39-0
benzyl bromide

: 359821-16-2
17-benzyl 16-tert-butyl 5-methyl (5S,16S,17R)-19-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-4,10-diazaicosane-5,16,17-tricarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / DBU / benzene / 4 h / Heating

2.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C

2.2: 64 percent / aq. H₂O₂; AcONa / tetrahydrofuran / 0.33 h / 0 °C

3.1: 91 percent / NMM / CH₂Cl₂ / 20 °C

4.1: 91 percent / K₂CO₃ / dimethylformamide / 2 h / 50 °C

With 4-methyl-morpholine; 9-borabicyclo[3.3.1]nonane dimer; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm010127e

Reference yield:

: 191406-75-4
4-benzyl 1-tert-butyl (2S,3R)-2-(3-hydroxypropyl)-3-isobutylbutanedioate

: 359821-16-2
17-benzyl 16-tert-butyl 5-methyl (5S,16S,17R)-19-methyl-3,11-dioxo-1-phenyl-2,12-dioxa-4,10-diazaicosane-5,16,17-tricarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NMM / CH₂Cl₂ / 20 °C

2: 91 percent / K₂CO₃ / dimethylformamide / 2 h / 50 °C

With 4-methyl-morpholine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010127e