Technology Process of ethyl 3-deoxy-5,6:7,8-di-O-isopropylidene-D-gluco-oct-2-ulosonate (E)-phenylhydrazone
There total 7 articles about ethyl 3-deoxy-5,6:7,8-di-O-isopropylidene-D-gluco-oct-2-ulosonate (E)-phenylhydrazone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / imidazole / dimethylformamide / 12 h / 60 °C
2: 70 percent / aq. LiOH / tetrahydrofuran / 40 h / 20 °C
3: DCC / CH2Cl2 / 1 h / 0 °C
4: CH2Cl2 / 1 h / -30 °C / Photolysis
5: pyridine / CH2Cl2 / 12 h / -20 - 20 °C
6: TBAF / tetrahydrofuran / 20 °C
With
pyridine; 1H-imidazole; lithium hydroxide; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00865-1
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 70 percent / acetone; p-toluenesulphonic acid / methanol / 18 h / 20 °C
2: 95 percent / imidazole / dimethylformamide / 12 h / 60 °C
3: 70 percent / aq. LiOH / tetrahydrofuran / 40 h / 20 °C
4: DCC / CH2Cl2 / 1 h / 0 °C
5: CH2Cl2 / 1 h / -30 °C / Photolysis
6: pyridine / CH2Cl2 / 12 h / -20 - 20 °C
7: TBAF / tetrahydrofuran / 20 °C
With
pyridine; 1H-imidazole; lithium hydroxide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; acetone;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00865-1