Technology Process of allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate
There total 5 articles about allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
DOI:10.1039/c2cc38382a
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 20 °C
2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C / Inert atmosphere
With
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1039/c2cc38382a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: caesium carbonate / methanol; water / pH 7
1.2: 12 h / 0 - 20 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
3.1: sodium carbonate / water; 1,4-dioxane / 1.17 h / 0 °C
4.1: trifluoroacetic acid / dichloromethane / 20 °C
5.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C / Inert atmosphere
With
sodium carbonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; diethylamine; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1039/c2cc38382a
