allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate

Base Information

Chemical Name:allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate
CAS No.:1422363-48-1
Molecular Formula:C₁₉H₂₄N₂O₆
Molecular Weight:376.409
Hs Code.:

Synonyms:allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate

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Chemical Property of allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate

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Technology Process of allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate

There total 5 articles about allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 623-04-1
4-aminobenzenemethanol

: 91871-28-2
N-allyloxycarbonyl α-allyl-L-glutamate

: 1422363-48-1
allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1039/c2cc38382a

Reference yield:

: 1422363-58-3
C₁₆H₂₅NO₆

: 1422363-48-1
allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C / Inert atmosphere

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c2cc38382a

Reference yield:

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 1422363-48-1
allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / methanol; water / pH 7

1.2: 12 h / 0 - 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3.1: sodium carbonate / water; 1,4-dioxane / 1.17 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C / Inert atmosphere

With sodium carbonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; diethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1039/c2cc38382a