octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Base Information

Chemical Name:octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide
CAS No.:944457-66-3
Molecular Formula:C₄₃H₄₆N₄O₅
Molecular Weight:698.862
Hs Code.:

Synonyms:octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Suppliers and Price of octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

There total 5 articles about octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.1%

: 944457-75-4
[1-[4'-(7-benzyloxycarbamoyl-heptanoylamino)biphenyl-2-ylcarbamoyl]-2-(4-benzyloxy-phenyl)ethyl]carbamic acid tert-butyl ester

: 944457-66-3
octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm070178x

Reference yield:

: 944457-73-2
C₃₃H₃₃N₃O₆

: 944457-66-3
octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / SnCl₂ / methanol; dioxane / Heating

2: 49 percent / DIPEA; PyBOP / dimethylformamide / 20 °C

3: 74.1 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tin(ll) chloride; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070178x

Reference yield:

: 944457-74-3
[1-(4'-amino-biphenyl-2-ylcarbamoyl)-2-(4-benzyloxyphenyl)ethyl]carbamic acid tert-butyl ester

: 944457-66-3
octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / DIPEA; PyBOP / dimethylformamide / 20 °C

2: 74.1 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070178x