944457-73-2

Upstream product

• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 6272-52-2 2-(4-nitrophenyl)aniline 

Downstream Products

• 944457-75-4 [1-[4'-(7-benzyloxycarbamoyl-heptanoylamino)biphenyl-2-ylcarbamoyl]-2-(4-benzyloxy-phenyl)ethyl]carbamic acid tert-butyl ester 
• 944457-66-3 octanedioic acid {2'-[2-amino-3-(4-benzyloxyphenyl)propionylamino]biphenyl-4-yl}amide benzyloxyamide 
• 944457-74-3 [1-(4'-amino-biphenyl-2-ylcarbamoyl)-2-(4-benzyloxyphenyl)ethyl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

ISOFORM-SELECTIVE HDAC INHIBITORS

One aspect of the invention relates to isoform-selective HDAC inhibitors. Also provided are methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy. The invention also provides methods for treating cancer, methods for treating neurological diseases and methods for treating malaria. Additionally, the invention provides pharmaceutical compositions comprising an HDAC inhibitor of the invention; and kits comprising a an HDAC inhibitor of the invention.

Functional differences in epigenetic modulators - Superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies

We compare the ability of two structurally different classes of epigenetic modulators, namely, histone deacetylase (HDAC) inhibitors containing either a hydroxamate or a mercaptoacetamide as the zinc binding group, to protect cortical neurons in culture from oxidative stress-induced death. This study reveals that some of the mercaptoacetamide-based HDAC inhibitors are fully protective, whereas the hydroxamates show toxicity at higher concentrations. Our present results appear to be consistent with the possibility that the mercaptoacetamide-based HDAC inhibitors interact with a different subset of the HDAC isozymes [less activity at HDAC1 and 2 correlates with less inhibitor toxicity], or alternatively, are interacting selectively with only the cytoplasmic HDACs that are crucial for protection from oxidative stress.