(1,4-diazabicyclo-[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)-phenyl)furan-2-yl)methanone

Base Information

Chemical Name:(1,4-diazabicyclo-[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)-phenyl)furan-2-yl)methanone
CAS No.:753500-02-6
Molecular Formula:C₁₉H₁₉F₃N₂O₂
Molecular Weight:364.367
Hs Code.:

Synonyms:(1,4-diazabicyclo-[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)-phenyl)furan-2-yl)methanone

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Chemical Property of (1,4-diazabicyclo-[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)-phenyl)furan-2-yl)methanone

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Technology Process of (1,4-diazabicyclo-[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)-phenyl)furan-2-yl)methanone

There total 8 articles about (1,4-diazabicyclo-[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)-phenyl)furan-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61941-90-0
5-(3-(trifluoromethyl)phenyl)furan-2-carbonyl chloride

: 150208-70-1
1,4-diazabicyclo[3.2.2]nonane dihydrochloride

: 753500-02-6
(1,4-diazabicyclo-[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)-phenyl)furan-2-yl)methanone

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; pH=8 - 9; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112669

Reference yield:

: 585-70-6
5-bromo-furan-2-carboxylic acid

: 753500-02-6
(1,4-diazabicyclo-[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)-phenyl)furan-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 24 h / Inert atmosphere; Reflux

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / Inert atmosphere; Reflux

3: sodium hydroxide / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: thionyl chloride / Reflux

5: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / pH 8 - 9 / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sulfuric acid; sodium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2020.112669

Reference yield:

: 35423-17-7
3-quinuclidone oxime

: 753500-02-6
(1,4-diazabicyclo-[3.2.2]nonan-4-yl)(5-(3-(trifluoromethyl)-phenyl)furan-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: polyphosphoric acid / 6 h / 130 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 0 °C / Inert atmosphere; Reflux

2.2: 20 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / pH 8 - 9 / Inert atmosphere

With lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2020.112669