{4-[3-(4-hydroxymethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanol

Base Information

• Chemical Name: {4-[3-(4-hydroxymethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanol
• CAS No.: 565462-34-2
• Molecular Formula: C₂₂H₂₂O₄
• Molecular Weight: 350.414
• Mol file: 565462-34-2.mol

Synonyms:{4-[3-(4-hydroxymethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanol

Chemical Property of {4-[3-(4-hydroxymethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[3-(4-hydroxymethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanol

There total 6 articles about {4-[3-(4-hydroxymethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4,4′-[1,3-phenylenebis(methyleneoxy)]bisbenzaldehyde (163301-09-5) → {4-[3-(4-hydroxymethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanol (565462-34-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 4h;

DOI:10.1016/S0040-4039(03)00442-8

Reference yield: 90.0%

C24H22O6 (64879-82-9) → {4-[3-(4-hydroxymethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanol (565462-34-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 8h; Heating;

DOI:10.1081/SCC-100106213

Reference yield:

1,3-bis-(bromomethyl)benzene (626-15-3) → {4-[3-(4-hydroxymethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanol (565462-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃ / dimethylformamide / 48 h / 60 °C

2: 95 percent / NaBH₄ / methanol / 6 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2004.01.008

upstream raw materials:

C₂₄H₂₂O₆

4,4′-[1,3-phenylenebis(methyleneoxy)]bisbenzaldehyde

4-hydroxy-benzaldehyde

1,3-bis-(bromomethyl)benzene

Downstream raw materials:

C₂₂H₂₀Br₂O₂

{4-[3-(4-mercaptomethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanethiol

C₃₆H₃₄N₂O₂

C₃₇H₃₃N₂O₂⁽¹⁺⁾*Cl^(1-)