5-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7-yl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3.4-b]pyridin-6(7H)-one

Base Information

Chemical Name:5-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7-yl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3.4-b]pyridin-6(7H)-one
CAS No.:1080562-42-0
Molecular Formula:C₂₄H₁₉F₂N₅O₂
Molecular Weight:447.444
Hs Code.:

Synonyms:5-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7-yl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3.4-b]pyridin-6(7H)-one

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Chemical Property of 5-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7-yl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3.4-b]pyridin-6(7H)-one

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Technology Process of 5-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7-yl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3.4-b]pyridin-6(7H)-one

There total 4 articles about 5-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7-yl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3.4-b]pyridin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 909185-85-9
N-cyclopropyl-7-iodo-6-methylbenzo[d]isoxazol-3-amine

: 1080562-57-7
5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

: 1080562-42-0
5-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7-yl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3.4-b]pyridin-6(7H)-one

Guidance literature:: N-cyclopropyl-7-iodo-6-methylbenzo[d]isoxazol-3-amine; With triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; palladium diacetate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; In tetrahydrofuran; 1,4-dioxane; at 100 ℃; for 0.333333h; Sealed glass; Microwave irradiation;

5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; at 20 - 110 ℃; for 5h;

Reference yield:

: 1080562-66-8
5-amino-1-(2,6-difluorophenyl)-1H-pyrazole-4-carbaldehyde

: 1080562-42-0
5-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7-yl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3.4-b]pyridin-6(7H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / ethanol / 75 °C

2.1: lithium hydroxide; water / acetonitrile / 1 h / 90 °C

2.2: 2 h / 20 - 35 °C

3.1: sodium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 16.33 h / 20 - 40 °C

4.1: triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / palladium diacetate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl / tetrahydrofuran; 1,4-dioxane / 0.33 h / 100 °C / Sealed glass; Microwave irradiation

4.2: 5 h / 20 - 110 °C

With piperidine; lithium hydroxide; water; sodium hydride; triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; palladium diacetate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; acetonitrile; 4.2: Suzuki Coupling;

Reference yield:

: 1080562-55-5
5-bromo-1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

: 1080562-42-0
5-(3-(cyclopropylamino)-6-methylbenzo[d]isoxazol-7-yl)-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3.4-b]pyridin-6(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 16.33 h / 20 - 40 °C

2.1: triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / palladium diacetate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl / tetrahydrofuran; 1,4-dioxane / 0.33 h / 100 °C / Sealed glass; Microwave irradiation

2.2: 5 h / 20 - 110 °C

With sodium hydride; triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; palladium diacetate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; N,N-dimethyl-formamide; 2.2: Suzuki Coupling;