5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Base Information

Chemical Name:5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one
CAS No.:1080562-57-7
Molecular Formula:C₁₃H₈BrF₂N₃O
Molecular Weight:340.127
Hs Code.:

Synonyms:5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

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Chemical Property of 5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

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Technology Process of 5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

There total 14 articles about 5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1080562-55-5
5-bromo-1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

: 74-88-4
methyl iodide

: 1080562-57-7
5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Guidance literature:: 5-bromo-1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one; With lithium tert-butoxide; In tetrahydrofuran; at 20 - 30 ℃; Large scale reaction;

methyl iodide; In tetrahydrofuran; at 40 ℃; for 18h;
DOI:10.1021/op100205s

Reference yield:

: 1080562-55-5
5-bromo-1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

: 77-78-1
dimethyl sulfate

: 1080562-57-7
5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

: 1256346-85-6
C₁₃H₈BrF₂N₃O

Guidance literature:: 5-bromo-1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one; With lithium hydride; In tetrahydrofuran; at 20 - 30 ℃;

dimethyl sulfate; In tetrahydrofuran; at 70 ℃; for 6h;
DOI:10.1021/op100205s

Reference yield:

: 1080562-66-8
5-amino-1-(2,6-difluorophenyl)-1H-pyrazole-4-carbaldehyde

: 1080562-57-7
5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine / ethanol / 7 h / Reflux; Large scale reaction

1.2: Reflux

2.1: N-Bromosuccinimide; lithium acetate / tetrahydrofuran; water / 6 h / 20 - 50 °C / Large scale reaction

3.1: lithium tert-butoxide / tetrahydrofuran / 20 - 30 °C / Large scale reaction

3.2: 18 h / 40 °C

With piperidine; N-Bromosuccinimide; lithium acetate; lithium tert-butoxide; In tetrahydrofuran; ethanol; water; 1.1: Knoevenagel condensation / 2.1: Hunsdiecker reaction;
DOI:10.1021/op100205s