(S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid

Base Information

Chemical Name:(S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid
CAS No.:1404380-71-7
Molecular Formula:C₁₈H₁₈F₃N₅O₅
Molecular Weight:441.367
Hs Code.:

Synonyms:(S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid

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Chemical Property of (S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid

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Technology Process of (S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid

There total 5 articles about (S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1404380-70-6
(S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid methyl ester

: 1404380-71-7
(S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid

Guidance literature:: (S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid methyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In water; ethyl acetate; pH=2;

Reference yield:

: 4668-42-2
(S)-2-benzyloxycarbonylamino-succinic acid 1-methyl ester

: 1404380-71-7
(S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 4 h / Reflux

2.1: sodium hydroxide; water / methanol / 2 h / 20 °C

2.2: pH 2

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;

Reference yield:

: 1152-61-0
N-Cbz-L-Asp

: 1404380-71-7
(S)-2-((benzyloxycarbonyl)amino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic anhydride / 16 h

2.1: ethyl acetate / 5 h / 20 °C

2.3: pH 2

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 4 h / Reflux

4.1: sodium hydroxide; water / methanol / 2 h / 20 °C

4.2: pH 2

With water; acetic anhydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; ethyl acetate;