3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propan-1-ol

Base Information

Chemical Name:3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propan-1-ol
CAS No.:473670-89-2
Molecular Formula:C₂₆H₄₆O₅Si
Molecular Weight:466.734
Hs Code.:

Synonyms:3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propan-1-ol

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Chemical Property of 3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propan-1-ol

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Technology Process of 3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propan-1-ol

There total 10 articles about 3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 314774-16-8
3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propyl acetate

: 473670-89-2
3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1039/b201228f

Reference yield:

: 314774-15-7
2-[(4R)-4-tert-butyldimethylsilyloxy-2,6,6,-trimethylcyclohex-1-enyl]ethyl acetate

: 473670-89-2
3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 28 percent / MCPBA / CH₂Cl₂ / 1 h / 0 °C

2: 63 percent / (p-BrC₆H₄)3N(+)*SbCl₆(-) / CH₂Cl₂ / 0.5 h / 20 °C

3: 78 percent / NaBH₄ / methanol / 0.5 h / 0 °C

4: 80 percent / (i-Pr)2NEt / CH₂Cl₂ / 16 h / 20 °C

5: 99 percent / LAH / diethyl ether / 0.5 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; tris(p-bromophenylammoniumyl) hexachloroantimonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; diethyl ether; dichloromethane;
DOI:10.1039/b201228f

Reference yield:

: 314774-12-4
2-[(1S,4S,6R)-4-tert-butyldimethylsilyloxy-2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl]ethyl acetate

: 473670-89-2
3-[(1R,4S)-4-tert-butyldimethylsilyloxy-1,2,2-trimethylcyclopentyl]-3-{[(4-methoxyphenyl)methoxy]methoxy}propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / (p-BrC₆H₄)3N(+)*SbCl₆(-) / CH₂Cl₂ / 0.5 h / 20 °C

2: 78 percent / NaBH₄ / methanol / 0.5 h / 0 °C

3: 80 percent / (i-Pr)2NEt / CH₂Cl₂ / 16 h / 20 °C

4: 99 percent / LAH / diethyl ether / 0.5 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; tris(p-bromophenylammoniumyl) hexachloroantimonate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1039/b201228f