2-Amino-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid

Base Information

Chemical Name:2-Amino-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid
CAS No.:16063-98-2
Molecular Formula:C6H7F6NO2
Molecular Weight:239.12
Hs Code.:
Mol file:16063-98-2.mol

Synonyms:HEXAFLUOROLEUCINE

Suppliers and Price of 2-Amino-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-Amino-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid

Chemical Property:

Melting Point:>220°C
Boiling Point:196.1°Cat760mmHg
PKA:2.14±0.10(Predicted)
Flash Point:72.4°C
PSA：63.32000
Density:1.499g/cm³
LogP:2.22950

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Amino-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid

There total 6 articles about 2-Amino-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(benzylamino)-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid

: 16063-98-2,16198-60-0
2-amino-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid

Guidance literature:: With 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; In methanol; at 35 ℃; for 17h;

Reference yield:

: 4,4,4-trifluoro-N-methoxy-N-methyl-3-(trifluoromethyl)but-2-enamide

: 16063-98-2,16198-60-0
2-amino-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 16 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

3: acetic acid / diethyl ether / 17 h / 0 °C

4: hydrogenchloride; acetic acid / water / 40 h / 100 °C

5: hydrogen; acetic acid; 20% palladium hydroxide-activated charcoal / methanol / 17 h / 35 °C

With hydrogenchloride; lithium aluminium tetrahydride; 10 wt% Pd(OH)2 on carbon; 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; In tetrahydrofuran; methanol; diethyl ether; water;

Reference yield:

: 4,4,4-trifluoro-N-methoxy-N-methyl-3-(trifluoromethyl)butanamide

: 16063-98-2,16198-60-0
2-amino-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

2: acetic acid / diethyl ether / 17 h / 0 °C

3: hydrogenchloride; acetic acid / water / 40 h / 100 °C

4: hydrogen; acetic acid; 20% palladium hydroxide-activated charcoal / methanol / 17 h / 35 °C

With hydrogenchloride; lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; In tetrahydrofuran; methanol; diethyl ether; water;