(S)-5,5,5,5',5',5'-hexafluoroleucine

Base Information

Chemical Name:(S)-5,5,5,5',5',5'-hexafluoroleucine
CAS No.:149560-64-5
Molecular Formula:C₆H₇F₆NO₂
Molecular Weight:239.117
Hs Code.:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5,5,5,5',5',5'-hexafluoroleucine

Chemical Property:

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Technology Process of (S)-5,5,5,5',5',5'-hexafluoroleucine

There total 14 articles about (S)-5,5,5,5',5',5'-hexafluoroleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (S)-2-(benzyloxycarbonylamino)-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid

: 478548-21-9
tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate

: 149560-64-5,16198-60-0
(S)-5,5,5,5',5',5'-hexafluoroleucine

Guidance literature:: tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;

(S)-2-(benzyloxycarbonylamino)-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid; With hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield: 92.0%

: 478548-21-9
tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate

: 149560-64-5,16198-60-0
(S)-5,5,5,5',5',5'-hexafluoroleucine

Guidance literature:: tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;

With hydrogen; 10percent Pd/C; In methanol; Further stages.;
DOI:10.1021/ol026922j