H-GLY-GLY-GLY-OET HCL

Base Information

• Chemical Name: H-GLY-GLY-GLY-OET HCL
• CAS No.: 16194-06-2
• Molecular Formula: C8H15 N3 O4 . Cl H
• Molecular Weight: 253.68
• Hs Code.: 2924199090
• Mol file: 16194-06-2.mol

Synonyms:Glycine,N-(N-glycylglycyl)-, ethyl ester, monohydrochloride (8CI); Glycine,glycylglycyl-, ethyl ester, monohydrochloride (9CI); Glycylglycylglycine ethylester hydrochloride

Chemical Property of H-GLY-GLY-GLY-OET HCL

Chemical Property:

• PSA: 110.52000
• LogP: 0.02470
• Storage Temp.: -15°C

Purity/Quality:

97% ^*data from raw suppliers

H-Gly-Gly-Gly-OEthydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: H-Gly-Gly-Gly-OEt HCl

Technology Process of H-GLY-GLY-GLY-OET HCL

There total 7 articles about H-GLY-GLY-GLY-OET HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-benzyloxycarbonyl-glycyl=>glycyl=>-glycine ethyl ester (2503-35-7) → glycyl-glycyl-glycine ethyl ester hydrochloride (16194-06-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium; In methanol;

DOI:10.1246/bcsj.57.97

Reference yield: 83.0%

glycine-glycine-glycine (556-33-2) + ethanol (64-17-5) → glycyl-glycyl-glycine ethyl ester hydrochloride (16194-06-2)

Guidance literature:

With thionyl chloride; for 4h; Heating;

DOI:10.1039/b607999g

Reference yield:

glycylglycine ethyl ester (627-74-7) → glycyl-glycyl-glycine ethyl ester hydrochloride (16194-06-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NMM, ECF, 2) NMM / 1) THF, -5 deg C, 10 min, 2) DMF, 1 h; r.t., overnight

2: 87 percent / 0.3 M hydrogen chloride, H₂ / Pd black / methanol

With 4-methyl-morpholine; hydrogenchloride; hydrogen; chloroformic acid ethyl ester; palladium; In methanol;

DOI:10.1246/bcsj.57.97

upstream raw materials:

glycine-glycine-glycine

ethanol

N-benzyloxycarbonyl-glycyl=>glycyl=>-glycine ethyl ester

glycine ethyl ester hydrochloride

Downstream raw materials:

Boc-L-Phe-(Gly)3-OEt

N-(meta-(ferrocenyl)-benzoyl)-glycyl-glycyl-glycine ethylester

N-(ortho-(ferrocenyl)-benzoyl)-glycyl-glycyl-glycine ethyl ester

N-(para-(ferrocenyl)-benzoyl)-glycyl-glycyl-glycine ethylester