2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(methylamino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

Base Information

Chemical Name:2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(methylamino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane
CAS No.:1346502-80-4
Molecular Formula:C₅₃H₇₅FN₄O₁₃
Molecular Weight:995.196
Hs Code.:

Synonyms:2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(methylamino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

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Chemical Property of 2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(methylamino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

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Technology Process of 2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(methylamino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

There total 14 articles about 2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(methylamino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1346502-77-9
2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

: 1346502-80-4
2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(methylamino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

Guidance literature:: With dimethylsulfide; trifluoroacetic acid; at 20 ℃;
DOI:10.1021/jm2009106

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 1346502-80-4
2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(methylamino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

Guidance literature:: Multi-step reaction with 10 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.92 h / 150 °C / Microwave irradiation

2.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 2.25 h / 65 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4.2: 0 - 20 °C

5.1: pyridinium p-toluenesulfonate / ethanol / 55 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

6.2: 0 - 20 °C

7.1: pyridinium p-toluenesulfonate / ethanol / 55 °C

8.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

9.1: tetrabutyl ammonium fluoride / 70 °C

10.1: dimethylsulfide; trifluoroacetic acid / 20 °C

With dmap; dimethylsulfide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; palladium diacetate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Williamson synthesis / 4.2: Williamson synthesis;
DOI:10.1021/jm2009106

Reference yield:

: 937183-61-4
4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene

: 1346502-80-4
2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(methylamino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 2.25 h / 65 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 0 - 20 °C

4.1: pyridinium p-toluenesulfonate / ethanol / 55 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

5.2: 0 - 20 °C

6.1: pyridinium p-toluenesulfonate / ethanol / 55 °C

7.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

8.1: tetrabutyl ammonium fluoride / 70 °C

9.1: dimethylsulfide; trifluoroacetic acid / 20 °C

With dmap; dimethylsulfide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; palladium diacetate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Williamson synthesis / 3.2: Williamson synthesis;
DOI:10.1021/jm2009106