2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

Base Information

Chemical Name:2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane
CAS No.:1346502-77-9
Molecular Formula:C₆₃H₉₁FN₄O₁₇
Molecular Weight:1195.43
Hs Code.:

Synonyms:2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

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Chemical Property of 2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

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Technology Process of 2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

There total 14 articles about 2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1346502-71-3
2-(1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethyl 4-methylbenzenesulfonate

: 1346502-77-9
2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

Guidance literature:: With tetrabutyl ammonium fluoride; at 70 ℃;
DOI:10.1021/jm2009106

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 1346502-77-9
2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.92 h / 150 °C / Microwave irradiation

2.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 2.25 h / 65 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4.2: 0 - 20 °C

5.1: pyridinium p-toluenesulfonate / ethanol / 55 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

6.2: 0 - 20 °C

7.1: pyridinium p-toluenesulfonate / ethanol / 55 °C

8.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

9.1: tetrabutyl ammonium fluoride / 70 °C

With dmap; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; palladium diacetate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Williamson synthesis / 4.2: Williamson synthesis;
DOI:10.1021/jm2009106

Reference yield:

: 937183-61-4
4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene

: 1346502-77-9
2-(2-fluoroethoxy)-1,3-di((E)-2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propane

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 2.25 h / 65 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 0 - 20 °C

4.1: pyridinium p-toluenesulfonate / ethanol / 55 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

5.2: 0 - 20 °C

6.1: pyridinium p-toluenesulfonate / ethanol / 55 °C

7.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

8.1: tetrabutyl ammonium fluoride / 70 °C

With dmap; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; palladium diacetate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Williamson synthesis / 3.2: Williamson synthesis;
DOI:10.1021/jm2009106