5-Cyano-4-(4-methoxy-phenyl)-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

Base Information

• Chemical Name: 5-Cyano-4-(4-methoxy-phenyl)-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide
• CAS No.: 201280-71-9
• Molecular Formula: C₂₁H₁₇N₃O₂S
• Molecular Weight: 375.451

Synonyms:5-Cyano-4-(4-methoxy-phenyl)-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

Chemical Property of 5-Cyano-4-(4-methoxy-phenyl)-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

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Technology Process of 5-Cyano-4-(4-methoxy-phenyl)-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide

There total 6 articles about 5-Cyano-4-(4-methoxy-phenyl)-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-cyano-3-(4-methoxyphenyl)thioacrylamide (39145-31-8) + N-phenylacetoacetamide (102-01-2,98624-45-4) → C21H17N3O2S (201280-71-9)

Guidance literature:

2-cyano-3-(4-methoxyphenyl)thioacrylamide; N-phenylacetoacetamide; With piperidine; In ethanol; for 1h; Reflux;

With hydrogenchloride; In ethanol; water;

DOI:10.1080/00397910802379199

Reference yield: 81.0%

N-phenylacetoacetamide (102-01-2,98624-45-4) + 2-cyano-3-(4-methoxyphenyl)thioacrylamide (68029-57-2) → 5-Cyano-4-(4-methoxy-phenyl)-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide (201280-71-9)

Guidance literature:

With 4-methyl-morpholine; In ethanol; at 20 ℃; for 4h;

DOI:10.1007/BF02321397

Reference yield:

C5H11N*C21H19N3O2S (1125735-20-7) → 5-Cyano-4-(4-methoxy-phenyl)-2-methyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid phenylamide (201280-71-9)

Guidance literature:

With hydrogenchloride; at 30 ℃;

DOI:10.1080/15257770.2018.1457161

upstream raw materials:

N-phenylacetoacetamide

2-cyano-3-(4-methoxyphenyl)thioacrylamide

C₅H₁₁N*C₂₁H₁₉N₃O₂S

2-cyano-3-(4-methoxyphenyl)thioacrylamide

Downstream raw materials:

[3-Cyano-4-(4-methoxy-phenyl)-6-methyl-5-phenylcarbamoyl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester

3-Amino-2-(4-bromo-benzoyl)-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-5-carboxylic acid phenylamide

6-[2-(4-Bromo-phenyl)-2-oxo-ethylsulfanyl]-5-cyano-4-(4-methoxy-phenyl)-2-methyl-N-phenyl-nicotinamide

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