39145-31-8Relevant academic research and scientific papers
Multicomponent Synthesis and Molecular and Crystal Structure of New Derivatives of Partially Hydrogenated Quinolines
Dorovatovskii, P. V.,Dyachenko, I. V.,Dyachenko, V. D.,Khrustalev, V. N.,Nenaidenko, V. G.
, p. 1824 - 1833 (2021/12/22)
Abstract: The multicomponent condensation of aromatic aldehydes, cyanothioacetamide, 1-(cyclohex-1-en-1-yl)azepine, and α-halocarbonyl compounds was studied. As a result, new derivatives of partially hydrogenated quinolines were synthesized. The molecular and crystal structures of a number of the synthesized heterocycles were studied X-ray analysis.
Dihydro-2: H -thiopyran-3(4 H)-one-1,1-dioxide-a versatile building block for the synthesis of new thiopyran-based heterocyclic systems
Palchykov, Vitalii A.,Chabanenko, Roman M.,Konshin, Valeriy V.,Dotsenko, Victor V.,Krivokolysko, Sergey G.,Chigorina, Elena A.,Horak, Yuriy I.,Lytvyn, Roman Z.,Vakhula, Andriy A.,Obushak, Mykola D.,Mazepa, Alexander V.
, p. 1403 - 1412 (2018/02/06)
Three series of new cyclic sulfones have been prepared by a one-pot multi-component reaction (MCR) starting from the readily available dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide. The in silico screening of the synthesized compounds revealed their high anti-inflammatory, antiarthritic, antiasthmatic and antiallergic potential coupled with the strong probability levels of cystinyl aminopeptidase inhibition. The key structures were confirmed by 2D NMR techniques.
Design and synthesis of pyrido[2,1- b ][1,3,5]thiadiazine library via uncatalyzed mannich-type reaction
Dotsenko, Victor V.,Frolov, Konstantin A.,Pekhtereva, Tatyana M.,Papaianina, Olena S.,Suykov, Sergey Yu.,Krivokolysko, Sergey G.
, p. 543 - 550 (2014/12/10)
This Research Article describes the synthesis of an over 700-member library of (8R/8S)-3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazin-9-carbonitriles by uncatalyzed Mannich-type reaction of N-methylmorpholinium (4R/4S)-4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridin-2-thiolates with a set of primary amines and excessive HCHO. The scope and limitations of the reaction were studied. Starting thiolates were obtained in yields of 53-82% by multicomponent reaction of aromatic aldehydes, cyanothioacetamide, 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid), and N-methylmorpholine, followed by heterocyclization of the resulting Michael adducts.
Regioselective reduction of 2-cyanoprop-2-enethioamides with sodium borohydride
Dotsenko,Krivokolysko
, p. 2261 - 2264 (2013/10/01)
Treatment of 2-cyanoprop-2-enethioamides with NaBH4 in EtOH gave C-alkylated cyanothioacetamides in 62-69% yields.
The behaviour of arylidenemalononitriles towards certain thiating phosphorus reagents
Abd El-Rahman, Naglaa M.
, p. 465 - 468 (2007/10/03)
The behaviour of arylidenemalononitriles 1, 2 and 3 towards certain thiating phosphorus reagents, namely, phosphorus pentasulfide and Lawesson's reagent 10, has been outlined. The products obtained depend on the nature of reactants. Analytical and spectro
Organophosphorus chemistry, 291. The action of 2,4-bis-(4-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide (Lawesson's reagent) on α, ss-unsaturated nitriles
Khidre, Maha D.,Yakout, El-Sayed M.A.,Refat, Mohamed,Mahran
, p. 119 - 125 (2007/10/03)
The reaction of 2,4-bis-(4-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide (Lawesson's reagent. LR, 1) with ylidenemalononitriles (5a-f) was studied. Partial hydrolysis of 5a-f followed by thiation with LR yields the respective thioamides 7a-f. Nuc
Condensation of α-cyanothioacetamide with aldehydes catalyzed by Envirocat EPZG
Bandgar,Zirange,Wadgaonkar
, p. 1153 - 1156 (2007/10/03)
Condensation of α-cyanothioacetamide with aldehydes has been carried out in excellent yield under mild conditions by using Envirocat EPZG as a heterogenous reusable catalyst.
