(1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6'-(benzyloxymethyl)-5-fluoro-3',4',5',5'-tetrahydro-6-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2'-[2H]pyran]

Base Information

Chemical Name:(1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6'-(benzyloxymethyl)-5-fluoro-3',4',5',5'-tetrahydro-6-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2'-[2H]pyran]
CAS No.:1004779-88-7
Molecular Formula:C₄₂H₄₁FO₇
Molecular Weight:676.782
Hs Code.:

Synonyms:(1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6'-(benzyloxymethyl)-5-fluoro-3',4',5',5'-tetrahydro-6-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2'-[2H]pyran]

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Chemical Property of (1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6'-(benzyloxymethyl)-5-fluoro-3',4',5',5'-tetrahydro-6-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2'-[2H]pyran]

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Technology Process of (1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6'-(benzyloxymethyl)-5-fluoro-3',4',5',5'-tetrahydro-6-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2'-[2H]pyran]

There total 3 articles about (1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6'-(benzyloxymethyl)-5-fluoro-3',4',5',5'-tetrahydro-6-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2'-[2H]pyran] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005142-78-8
C₅₀H₅₉FO₁₀

: (1R,3'R,4'S,5'R,6'R)-3',4',5'-tris-benzyloxy-6'-benzyloxymethyl-5-fluoro-5-hydroxymethyl-3',4',5',6'-tetrahydro-spiro[isobenzofuro-1(3H),2'-[2H]pyran]

: 1004779-88-7
(1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6'-(benzyloxymethyl)-5-fluoro-3',4',5',5'-tetrahydro-6-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2'-[2H]pyran]

Guidance literature:: With water; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 1004779-90-1
(1S,3'R,4'S,5'R,6'R)-3',4',5'-tris-benzyloxy-6'-benzyloxymethyl-5-fluoro-6-formyl-3',4',5',6'-tetrahydro-spiro[isobenzofuro-1(3H),2'-[2H]pyran]

: 75-16-1
methylmagnesium bromide

: 1004779-88-7
(1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6'-(benzyloxymethyl)-5-fluoro-3',4',5',5'-tetrahydro-6-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2'-[2H]pyran]

Guidance literature:: (1S,3'R,4'S,5'R,6'R)-3',4',5'-tris-benzyloxy-6'-benzyloxymethyl-5-fluoro-6-formyl-3',4',5',6'-tetrahydro-spiro[isobenzofuro-1(3H),2'-[2H]pyran]; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; Product distribution / selectivity;

Reference yield:

: (1R,3'R,4'S,5'R,6'R)-3',4',5'-tris-benzyloxy-6'-benzyloxymethyl-5-fluoro-5-hydroxymethyl-3',4',5',6'-tetrahydro-spiro[isobenzofuro-1(3H),2'-[2H]pyran]

: 1004779-88-7
(1S,3'R,4'S,5'R,6'R)-3',4',5'-tris(benzyloxy)-6'-(benzyloxymethyl)-5-fluoro-3',4',5',5'-tetrahydro-6-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2'-[2H]pyran]

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; methanol; for 2.5h; Product distribution / selectivity; Heating / reflux;