(R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile

Base Information

Chemical Name:(R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile
CAS No.:1414353-33-5
Molecular Formula:C₂₉H₂₆FN₇O₂
Molecular Weight:523.57
Hs Code.:

Synonyms:(R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile

Suppliers and Price of (R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile

There total 10 articles about (R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1414356-90-3
3-[(2R)-2-([4-amino-3-[4-(2-fluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1414353-33-5
(R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile

Guidance literature:: With piperidine; In methanol; dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 367-12-4
2-fluorophenol

: 1414353-33-5
(R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / copper(l) chloride / N,N-dimethyl-formamide; mineral oil / 5 h / 100 °C

2.1: ammonium chloride; iron / water; methanol / 1.33 h / 80 °C / Reflux

3.1: hydrogenchloride; sodium nitrite / 0.5 h / 0 °C

3.2: 0.33 h / 0 °C

3.3: 1 h / 20 °C

4.1: n-butyllithium / water; tetrahydrofuran / 0.17 h / -78 - 20 °C / pH 2 - 4 / Inert atmosphere

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1000 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

8.1: piperidine / dichloromethane; methanol / 1 h / 20 °C

With piperidine; hydrogenchloride; n-butyllithium; iron; sodium hydride; sodium carbonate; ammonium chloride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1414353-33-5
(R)-2-(2-((4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-3-cyclopropyl acrylonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / copper(l) chloride / N,N-dimethyl-formamide; mineral oil / 5 h / 100 °C

2.1: ammonium chloride; iron / water; methanol / 1.33 h / 80 °C / Reflux

3.1: hydrogenchloride; sodium nitrite / 0.5 h / 0 °C

3.2: 0.33 h / 0 °C

3.3: 1 h / 20 °C

4.1: n-butyllithium / water; tetrahydrofuran / 0.17 h / -78 - 20 °C / pH 2 - 4 / Inert atmosphere

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1000 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

8.1: piperidine / dichloromethane; methanol / 1 h / 20 °C

With piperidine; hydrogenchloride; n-butyllithium; iron; sodium hydride; sodium carbonate; ammonium chloride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;