benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester
• CAS No.: 929118-95-6
• Molecular Formula: C₄₆H₈₁NO₆Si₂
• Molecular Weight: 800.323

Synonyms:benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester

Chemical Property of benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester

There total 12 articles about benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester (929118-94-5) + benzyl bromide (100-39-0) → benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester (929118-95-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja0684996

Reference yield:

tert-butyl-(10,10-dimethoxy-deca-2,4-dienyloxy)-diphenyl-silane → benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester (929118-95-6)

Guidance literature:

Multi-step reaction with 12 steps

1.1: aq. LiBF₄ / acetonitrile / 5 h / 0 - 20 °C

2.1: 17.87 g / LiCl; i-Pr₂EtN / 1 h / 0 °C

3.1: 81 percent / Me₂AlCl / CH₂Cl₂ / 1.5 h / -78 - -30 °C

4.1: 92 percent / K₂OsO₄; NMO / acetone; 2-methyl-propan-2-ol / 60 h / pH 7.0

5.1: 90 percent / p-toluenesulfonic acid hydrate / acetone / 1.5 h

6.1: n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

6.2: 94 percent / tetrahydrofuran; hexane / 0.5 h / 0 °C

7.1: 94 percent / DIBAL-H / toluene / 0.17 h / -90 °C

8.1: 92 percent / LiCl; i-Pr₂EtN / acetonitrile / 24 h / 50 °C

9.1: 92 percent / DIBAL-H / toluene / -78 - -30 °C

10.1: TBAF; AcOH / tetrahydrofuran / 24 h

11.1: 91 percent / 2,6-lutidine / CH₂Cl₂ / 0.17 h / -78 °C

12.1: 98 percent / NaH / dimethylformamide; tetrahydrofuran

With 2,6-dimethylpyridine; potassium osmate(VI); lithium tetrafluoroborate; n-butyllithium; N-methyl-2-indolinone; tetrabutyl ammonium fluoride; dimethylaluminum chloride; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol; 2.1: Horner-Wadsworth-Emmons olefination / 3.1: Diels-Alder cycloaddition / 8.1: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/ja0684996

Reference yield:

10-(tert-butyl-diphenyl-silanyloxy)-deca-6,8-dienal (929118-77-4) → benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester (929118-95-6)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 17.87 g / LiCl; i-Pr₂EtN / 1 h / 0 °C

2.1: 81 percent / Me₂AlCl / CH₂Cl₂ / 1.5 h / -78 - -30 °C

3.1: 92 percent / K₂OsO₄; NMO / acetone; 2-methyl-propan-2-ol / 60 h / pH 7.0

4.1: 90 percent / p-toluenesulfonic acid hydrate / acetone / 1.5 h

5.1: n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

5.2: 94 percent / tetrahydrofuran; hexane / 0.5 h / 0 °C

6.1: 94 percent / DIBAL-H / toluene / 0.17 h / -90 °C

7.1: 92 percent / LiCl; i-Pr₂EtN / acetonitrile / 24 h / 50 °C

8.1: 92 percent / DIBAL-H / toluene / -78 - -30 °C

9.1: TBAF; AcOH / tetrahydrofuran / 24 h

10.1: 91 percent / 2,6-lutidine / CH₂Cl₂ / 0.17 h / -78 °C

11.1: 98 percent / NaH / dimethylformamide; tetrahydrofuran

With 2,6-dimethylpyridine; potassium osmate(VI); n-butyllithium; N-methyl-2-indolinone; tetrabutyl ammonium fluoride; dimethylaluminum chloride; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol; 1.1: Horner-Wadsworth-Emmons olefination / 2.1: Diels-Alder cycloaddition / 7.1: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/ja0684996

upstream raw materials:

{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester

benzyl bromide

10-(tert-butyl-diphenyl-silanyloxy)-deca-6,8-dienal

(3aS,4S,5R,5aS,9aS,9bR)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxole-5-carbaldehyde

Downstream raw materials:

benzyl-[(E)-(R)-5-hydroxy-7-(4-hydroxymethyl-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl)-1-methyl-hept-6-enyl]-carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 929118-95-6 benzyl-{5-(tert-butyl-dimethyl-silanyloxy)-7-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-1-methyl-hept-6-enyl}-carbamic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send