(R)-2-benzyl-2-fluoro-N-(2-fluoroethyl)-3-((R)-2-fluoropropanamido)propanamide

Base Information

Chemical Name:(R)-2-benzyl-2-fluoro-N-(2-fluoroethyl)-3-((R)-2-fluoropropanamido)propanamide
CAS No.:1391826-35-9
Molecular Formula:C₁₅H₁₉F₃N₂O₂
Molecular Weight:316.323
Hs Code.:

Synonyms:(R)-2-benzyl-2-fluoro-N-(2-fluoroethyl)-3-((R)-2-fluoropropanamido)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-benzyl-2-fluoro-N-(2-fluoroethyl)-3-((R)-2-fluoropropanamido)propanamide

Chemical Property:

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Technology Process of (R)-2-benzyl-2-fluoro-N-(2-fluoroethyl)-3-((R)-2-fluoropropanamido)propanamide

There total 4 articles about (R)-2-benzyl-2-fluoro-N-(2-fluoroethyl)-3-((R)-2-fluoropropanamido)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1391826-44-0
C₁₃H₁₅F₂NO₃

: 460-08-2
2-fluoroethylamine hydrochloride

: 1391826-35-9
(R)-2-benzyl-2-fluoro-N-(2-fluoroethyl)-3-((R)-2-fluoropropanamido)propanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1002/chem.201200313

Reference yield:

: 1391826-42-8
methyl (R)-3-amino-2-benzyl-2-fluoropropanoate trifluoroacetate

: 1391826-35-9
(R)-2-benzyl-2-fluoro-N-(2-fluoroethyl)-3-((R)-2-fluoropropanamido)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

2: water; lithium hydroxide / methanol / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/chem.201200313

Reference yield:

: 1391826-43-9
methyl (R)-2-benzyl-2-fluoro-3-((R)-2-fluoropropanamido)propanoate

: 1391826-35-9
(R)-2-benzyl-2-fluoro-N-(2-fluoroethyl)-3-((R)-2-fluoropropanamido)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol / 18 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/chem.201200313