460-08-2

Basic information

• Product Name: 2-FLUOROETHYLAMINE HYDROCHLORIDE
• Synonyms: beta-fluoroethylaminehydrochloride;2-FLUOROETHYLAMINE HYDROCHLORIDE;TIMTEC-BB SBB004369;2-FLUORETHYLAMIN HYDROCHLORID TECHN. 90%;2-FLUORETHANAMINEHYDROCHLORIDE;2-FLUORETHYLAMINEHYDROCHLORIDE;2-Fluoroethylamine hydrochloride 90%;2-FluorethylaMin hydrochloride
• CAS NO: 460-08-2
• Molecular Formula: C₂H₆FN*ClH
• Molecular Weight: 99.54
• EINECS: 207-302-3
• Product Categories: Amine Salts;Nitrogen Compounds;Organic Building Blocks
• Mol File: 460-08-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 99-103 °C(lit.)
• Boiling Point: 52.1 °C at 760 mmHg
• Flash Point: 20.7 °C
• Appearance: /
• Density: 0.892g/cm³
• Vapor Pressure: 269mmHg at 25°C
• Refractive Index: 1.345
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Soluble in water
• Sensitive: Hygroscopic
• CAS DataBase Reference: 2-FLUOROETHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROETHYLAMINE HYDROCHLORIDE(460-08-2)
• EPA Substance Registry System: 2-FLUOROETHYLAMINE HYDROCHLORIDE(460-08-2)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• RTECS: KR7570000
• HazardClass: IRRITANT, HYGROSCOPIC
• Hazardous Substances Data: 460-08-2(Hazardous Substances Data)

Usage

Uses

2-Fluoroethylamine hydrochloride may be used in the synthesis of the following:2-fluoroethylisocyanate1,3-bis-(2-fluoroethyl) urea (BFU)N-2-fluoroethylmaleimide[Cu4(O)(Ln)2(CH3COO)4] where HL= 4-methyl-2,6-bis(2-fluoroethyliminomethyl) phenol1-O-(4-(2-fluoroethyl-carbamoyloxymethyl)-2-nitrophenyl)-O-β-D-glucopyronuronate (FEAnGA)

General Description

2-Fluoroethylamine hydrochloride is a fluorinated alkylammonium salt. Studies suggest that adding a fluorine atom to it leads to double gauche effect in the resulting 2,2-difluoroethylamine chloride. Microwave spectral studies for 2-fluoroethylamine has been conducted.

InChI:InChI=1/C2H6FN/c3-1-2-4/h1-2,4H2

Upstream product

• 13880-61-0 N-<β-Fluor-ethyl>-B,B-difluor-borazan 
• 442-31-9 2-(2-fluoroethyl)isoindoline-1,3-dione 
• 894792-94-0 1-azido-2-fluoroethane 
• 371-62-0 2-fluoroethanol 

Downstream Products

• 33021-91-9 N-<2-Fluor-aethyl>-N'--harnstoff 
• 505-12-4 (2-fluoroethyl) isocyanate 
• 113220-16-9 ethyl 3-(2-fluoroethylamino)-2-(2,3,4, 5-tetrafluorobenzoyl) acrylate 
• 178181-52-7 tert-butyl (2-fluoroethyl)carbamate 
• 136455-77-1 3-bromo-N-(2-fluoroethyl)benzenesulfonamide 
• 1044256-58-7 1-(3-chloro-2-fluoro-benzyl)-3-(2-fluoro-ethyl)-urea 
• 1137522-83-8 6-benzyl-N-(2-fluoroethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 1365213-74-6 6-[(2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]-N-(2-fluoroethyl)imidazo[1,2-b]pyridazine-3-carboxamide 
• 1239235-00-7 2-({(2-(4-chlorophenyl)-1,3-thiazol-4-yl)methyl}sulfanyl)-6-((2-fluoroethyl)amino)-4-(4-(2-hydroxyethoxy)phenyl)pyridine-3,5-dicarbonitrile 
• 1062171-17-8 isopropyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amino}phenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate 
• 1062170-00-6 tert-butyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amino}phenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate 
• 1198178-20-9 1-(2-fluoroethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea 
• 1196713-79-7 C₁₈H₁₈FN₃O₂ 
• 1062169-42-9 methyl 4-[6-(4-([(2-fluoroethyl)carbamoyl]amino)phenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate 

Relevant articles and documents

Preparation method of 2-fluoroethylamine hydrochloride

The invention discloses a preparation method of 2-fluoroethylamine hydrochloride. The method comprises the following steps: S1, synthesis of 2-fluoroethyl phthalimide: adding 2-fluoro-1-haloethane and phthalimide potassium into a reaction container, performing dissolving with N,N-dimethylformamide under mechanical stirring, performing reacting, carrying out reduced pressure distillation to recover N,N-dimethylformamide after the reaction is finished, adding water into the reaction container, performing heating and stirring, and performing cooling, filtering and vacuum drying to obtain a 2-fluoroethyl phthalimide intermediate; and S2, synthesis of the 2-fluoroethylamine hydrochloride: adding the 2-fluoroethyl phthalimide intermediate prepared in the step S1 into the reaction container, performing dissolving with ethanol, dropwise adding hydrazine hydrate for reaction, performing cooling after the reaction is finished, adjusting the pH to 5 with hydrochloric acid, performing refluxing for 1 hour, and performing filtering and vacuum drying to obtain white flaky crystal 2-fluoroethylamine hydrochloride. The method is simple in process, green, safe, low in cost and high in yield.

Sustainable organophosphorus-catalysed Staudinger reduction

A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.

GROWTH HORMONE SECRETAGOGUES

This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.