2-Methyl-2-morpholinopropanal

Base Information

• Chemical Name: 2-Methyl-2-morpholinopropanal
• CAS No.: 16042-91-4
• Molecular Formula: C8H15 N O2
• Molecular Weight: 157.213
• Hs Code.: 2934999090
• European Community (EC) Number: 823-211-7
• DSSTox Substance ID: DTXSID70377236
• Wikidata: Q82166382
• Mol file: 16042-91-4.mol

Synonyms:2-methyl-2-morpholinopropanal;16042-91-4;2-methyl-2-(morpholin-4-yl)propanal;2-methyl-2-morpholin-4-ylpropanal;2-methyl-2-(4-morpholinyl)propanal;Ammoniumhydrogensulfate;2-methyl-2-morpholino-propanal;SCHEMBL1266718;DTXSID70377236;WWILHZQYNPQALT-UHFFFAOYSA-N;MFCD05663791;AKOS000275270;2-methyl-2-morpholinopropanal, AldrichCPR;FT-0680413;4-Morpholineacetaldehyde, alpha,alpha-dimethyl-;D84101;EN300-252317;4X-0733;J-509938;F2147-8791;Z1201623154

Chemical Property of 2-Methyl-2-morpholinopropanal

Chemical Property:

• Vapor Pressure: 0.229mmHg at 25°C
• Refractive Index: 1.464
• Boiling Point: 207.1°C at 760 mmHg
• PKA: 5.48±0.10(Predicted)
• Flash Point: 79.1°C
• PSA: 29.54000
• Density: 1.033g/cm³
• LogP: 0.23400
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 157.110278721
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

98%min ^*data from raw suppliers

2-methyl-2-morpholinopropanal ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C=O)N1CCOCC1

Technology Process of 2-Methyl-2-morpholinopropanal

There total 2 articles about 2-Methyl-2-morpholinopropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + 2-bromo-2-methylpropanal (13206-46-7) → 2-methyl-2-(morpholin-4-yl)propanal (16042-91-4)

Guidance literature:

With triethylamine; In diethyl ether; at 20 ℃;

Reference yield:

→ 2-methyl-2-(morpholin-4-yl)propanal (16042-91-4)

Guidance literature:

Enamin V, Dimethylchloramin;

Reference yield: 96.0%

(R)-N-(1-(2-cyanoacetyl)piperidin-3-yl)-5-(2-methyl-4-phenoxyphenyl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide + 2-methyl-2-(morpholin-4-yl)propanal (16042-91-4) → (R,E)-N-(1-(2-cyano-4-methyl-4-morpholinopent-2-enoyl)piperidin-3-yl)-5-(2-methyl-4-phenoxyphenyl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide

Guidance literature:

With piperidine; In ethanol; at 105 ℃; Sealed tube;

upstream raw materials:

morpholine

2-bromo-2-methylpropanal

Downstream raw materials:

(S)-2-(2-((4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-4-methyl-4-morpholinopent-2-enenitrile

(R)-2-(2-((4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)pyrrolidine-1-carbonyl)-4-methyl-4-morpholinopent-2-enenitrile

2-[2-[[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]azetidine-1-carbonyl]-4-methyl-4-morpholino-pent-2-enenitrile

(S)-2-(2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)-pyrrolidine-1-carbonyl)-4-methyl-4-morpholinopent-2-enenitrile

Refernces

• 1、 -. "IMMUNOPROTEASOME INHIBITORS". Paragraph 0285. . Retrieved 2018/08/20.