13206-46-7Relevant academic research and scientific papers
IMMUNOPROTEASOME INHIBITORS
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Paragraph 0420; 0441, (2019/06/13)
Provided herein are compounds, such as a compound of Formula (I), or a pharmaceutically acceptable salt thereof, that are immunoproteasome (such as LMP2 and LMP7) inhibitors. The compounds described herein can be useful for the treatment of diseases treatable by inhibition of immunoproteasomes. Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
IMMUNOPROTEASOME INHIBITORS
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Paragraph 0213, (2018/08/20)
Provided herein are compounds, such as a compound of Formula (I), as described herein, or a pharmaceutically acceptable salt thereof, that are immunoproteasome (such as LMP2 and LMP7) inhibitors. The compounds described herein can be useful for the treatment of diseases treatable by inhibition of immunoproteasomes. Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
TYROSINE KINASE INHIBITORS
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Page/Page column 75, (2017/04/19)
The present disclosure provides compounds of formula (I) that are tyrosine kinase inhibitors, in particular Bruton tyrosine kinase ("BTK") inhibitors, and are therefore useful for the treatment of diseases treatable by inhibition of BTK such as cancer, au
SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF
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Paragraph 0250; 0251, (2014/09/30)
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS
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Page/Page column 59; 64; 65-66; 67-68; 77; 78, (2014/03/26)
The present disclosure provides compounds of Formula (LA) and/ or pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BTK, and are potentially useful for the treatment of diseases treatable by inhibition of ty r-osine kinases such as cancer, inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and/or pharmaceutically acceptable salts thereof and processes for preparing such compounds and p h ar-maceutically acceptable salts thereof
Stereocontrolled 1,3-phosphatyloxy and 1,3-halogen migration relay toward highly functionalized 1,3-dienes
Kazem Shiroodi, Roohollah,Dudnik, Alexander S.,Gevorgyan, Vladimir
supporting information; experimental part, p. 6928 - 6931 (2012/06/15)
A double migratory cascade reaction of α-halogen-substituted propargylic phosphates to produce highly functionalized 1,3-dienes has been developed. This transformation features 1,3-phosphatyloxy group migration followed by 1,3-shifts of bromine and chlorine as well as the unprecedented 1,3-migration of iodine. The reaction is stereodivergent: (Z)-1,3-dienes are formed in the presence of a copper catalyst, whereas gold-catalyzed reactions exhibit inverted stereoselectivity, producing the corresponding E products.
Unsymmetrical bidentate ligands of α-aminoaldimines leading to sterically controlled selectivity of geometrical isomerism in square planar coordination
Lee, Jen-Jeh,Yang, Feng-Zhao,Lin, Ya-Fan,Chang, Ya-Chun,Yu, Kuo-Hsuan,Chang, Mu-Chieh,Lee, Gene-Hsiang,Liu, Yi-Hung,Wang, Yu,Liu, Shiuh-Tzung,Chen, Jwu-Ting
experimental part, p. 5945 - 5956 (2009/02/07)
New α-aminoaldimines with the formula of Et2NCMe 2CHNR (R = iPr, tBu, Ph) and their dichloro or diacetato complexes of Ni, Pd, Pt are prepared and structurally characterized. A nickel complex is in a distorted tetrahedral configuration, and the Pd and Pt complexes (4-6) are of square planar form. The α-aminoaldimines can chelate to the metal in a C2-unsymmetric bidentate motif through the hetero functionalities of amine and imine, which show comparable trans influence. Square planar organometallic palladium derivatives bearing α-aminoaldimines, including Pd-methyl, Pd-acetyl, and Pd- (η2-acetylnorboryl) (7-10), are also synthesized. The latter two species are a result of CO-insertion into Pd-methyl complexes and ensuing norbornene-insertion, respectively. The geometrical isomerism is found in the trans configuration in most studied cases. Such a stereoselectivity results from the thermodynamic stability governed predominantly by steric control. The stereoselectivity is also supported by DFT calculations.
Pharmaceutical compounds
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Page/Page column 89-90, (2008/06/13)
Compounds of Formulae Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES
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Page/Page column 185-186, (2008/12/08)
Methods of preventing, treating or delaying the onset of HIV in a subject by administering to the subject novel pharmaceutically active arylmethyl pyrazolo[1,5-α ]pyrimidine amide derivatives, or pharmaceutical compositions containing the same are described. Additionally, compounds of novel pharmaceutically active arylmethyl piperazine pyrazolo[l,5-α]pyrimidine amide derivatives and their use for the manufacture of specific medicaments are described.
Total synthesis of seco-lateriflorone
Tisdale, Eric J.,Vong, Binh G.,Li, Hongmei,Kim, Sun Hee,Chowdhury, Chinmay,Theodorakis, Emmanuel A.
, p. 6873 - 6887 (2007/10/03)
A convergent strategy toward the synthesis of lateriflorone (5) is described. Our approach is based on biosynthetic considerations and draws on a sequence of prenylation, oxygenation and Claisen reactions for the construction of chromenequinone 6, and a tandem Claisen/Diels-Alder reaction cascade for the synthesis of caged tricycle 7. Union of fragments 6 and 7 led to the synthesis of seco-lateriflorone (49).
